ArticleWorld journal of gastroenterology2012
Medical treatment for sphincter of oddi dysfunction: can it replace endoscopic sphincterotomy?
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02833103 (Application of Pinaverium Bromide in the Treatment of Patients With Post-cholecystectomy Sphincter of Oddi Dysfunction), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Application of Pinaverium Bromide in the Treatment of Patients With Post-cholecystectomy Sphincter of Oddi Dysfunction (SOD): A Randomized, Controlled and Multicenter Clinical Study
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Endoscopic sphincterotomy for adults with biliary sphincter of Oddi dysfunction.The Cochrane database of systematic reviews · 2024Pooled it
- Personalized Treatments for Functional Disorders of the Sphincter of Oddi: A Short Muscle with a Long History of Discussion and Controversies.Journal of personalized medicine · 2026Review
- Reassessing the role of nitric oxide in the pathogenesis of sphincter of Oddi dysfunction.Gastroenterology report · 2025Review
- Current treatment of biliary Sphincter of Oddi Dysfunction.Frontiers in medicine · 2024Review
- Dysfunction of Biliary Sphincter of Oddi-Clinical, Diagnostic and Treatment Challenges.Journal of clinical medicine · 2023Review
- Idiopathic acute pancreatitis: a review on etiology and diagnostic work-up.Clinical journal of gastroenterology · 2019Review
- Etiologies of Long-Term Postcholecystectomy Symptoms: A Systematic Review.Gastroenterology research and practice · 2019Review
- Sphincter of Oddi Dysfunction: Updates from the Recent Literature.Current gastroenterology reports · 2015Review
- Sphincter of Oddi dysfunction Type III: New studies suggest new approaches are needed.World journal of gastroenterology · 2015Review
- Spinal cord stimulation for intractable visceral pain due to sphincter of oddi dysfunction.The Korean journal of pain · 2015Article
- Clinical course of biliary-type sphincter of Oddi dysfunction: endoscopic sphincterotomy and functional dyspepsia as affecting factors.Therapeutic advances in gastrointestinal endoscopyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo report the results of a medical management of sphincter of oddi dysfunction (SOD) after an intermediate follow-up period.
methodsA total of 59 patients with SOD (2 men and 57 women, mean age 51 years old) were included in this prospective study. After medical treatment for one year, the patients were clinically re-evaluated after an average period of 30 mo.
resultsThe distribution of the patients according to the Milwaukee's classification was the following: 11 patients were type 1, 34 were type 2 and 14 were type 3. Fourteen patients underwent an endoscopic sphincterotomy (ES) after one year of medical treatment. The median intermediate follow-up period was 29.8 ± 3 mo (3-72 mo). The initial effectiveness of the medical treatment was complete, partial and poor among 50.8%, 13.5% and 35%, respectively, of the patients. At the end of the follow-up period, 37 patients (62.7%) showed more than 50% improvement. The rate of improvement in patients who required ES was not significantly different compared with the patients treated conservatively (64.2% vs 62.2%, respectively).
conclusionOur study confirms that conservative medical treatment could be an alternative to endoscopic sphincterotomy because, after an intermediate follow-up period, the two treatments show the same success rates.
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Registered trials
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