ArticleWorld journal of gastroenterology2012
Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Robust differentiation of human enteroendocrine cells from intestinal stem cells.Nature communications · 2022Article
- Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy.PloS one · 2014Article
- Disruption of prostate epithelial differentiation pathways and prostate cancer development.Frontiers in oncology · 2013Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimTo investigate the impact of phosphatase and tensin homolog (Pten) in the specification of intestinal enteroendocrine subpopulations.
methodsUsing the Cre/loxP system, a mouse with conditional intestinal epithelial Pten deficiency was generated. Pten mutant mice and controls were sacrificed and small intestines collected for immunofluorescence and quantitative real-time polymerase chain reaction. Blood was collected on 16 h fasted mice by cardiac puncture. Enzyme-linked immunosorbent assay was used to measure blood circulating ghrelin, somatostatin (SST) and glucose-dependent insulinotropic peptide (GIP) levels.
resultsResults show an unexpected dual regulatory role for epithelial Pten signalling in the specification/differentiation of enteroendocrine cell subpopulations in the small intestine. Our data indicate that Pten positively regulates chromogranin A (CgA) expressing subpopulations, including cells expressing secretin, ghrelin, gastrin and cholecystokinin (CCK). In contrast, Pten negatively regulates the enteroendocrine subtype specification of non-expressing CgA cells such as GIP and SST expressing cells.
conclusionThe present results demonstrate that Pten signalling favours the enteroendocrine progenitor to specify into cells expressing CgA including those producing CCK, gastrin and ghrelin.
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