ArticleProceedings of the National Academy of Sciences of the United States of America2012
Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 99 citations in OpenAlex.
- Intrinsically Disordered Polypeptides-Based Stealth Materials Enable Enhanced Photothermal Cancer Therapy Using an In Situ Fiber-Based Penetrating Laser System.Small science · 2026Article
- An integrated ultrasound-guided focused ultrasound system enables spatiotemporal control of thermal gene activation in engineered immune cells.Theranostics · 2026Article
- Rheological Behavior of an Aqueous Suspension of Oxidized Carbon Nanohorn (CNHox).Nanomaterials (Basel, Switzerland) · 2024Article
- Opto-thermal technologies for microscopic analysis of cellular temperature-sensing systems.Biophysical reviews · 2022Review
- A Narrative Review of Cell-Based Approaches for Cranial Bone Regeneration.Pharmaceutics · 2022Review
- Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes.Nature communications · 2020Article
- Near-infrared optogenetic engineering of photothermal nanoCRISPR for programmable genome editing.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Targeted heat activation of HSP promoters in the skin of mammalian animals and humans.Cell stress & chaperones · 2018Article
- Remote Control of Mammalian Cells with Heat-Triggered Gene Switches and Photothermal Pulse Trains.ACS synthetic biology · 2018Article
- Membrane heat shock protein 70: a theranostic target for cancer therapy.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Immobilization of a carbon nanomaterial-based localized drug-release system using a bispecific material-binding peptide.International journal of nanomedicine · 2018Article
- Surface chemistry for cytosolic gene delivery and photothermal transgene expression by gold nanorods.Scientific reports · 2017Article
- Light-driven liquid metal nanotransformers for biomedical theranostics.Nature communications · 2017Article
- Infrared laser-induced gene expression for tracking development and function of single C. elegans embryonic neurons.Nature communications · 2017Article
- Temporal and spatial patterning of transgene expression by near-infrared irradiation.Biomaterials · 2014Article
- Carbon nanotubes in hyperthermia therapy.Advanced drug delivery reviews · 2013Review
- Long-term biopersistence of tangled oxidized carbon nanotubes inside and outside macrophages in rat subcutaneous tissue.Scientific reports · 2013Article
- Functionalized multiwalled carbon nanotubes as ultrasound contrast agents.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Carbon nanotube-liposome supramolecular nanotrains for intelligent molecular-transport systems.Nature communications · 2012Article
- Carbonaceous Nanomaterials for Phototherapy of Cancer.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of optical methods to control cellular functions is important for various biological applications. In particular, heat shock promoter-mediated gene expression systems by laser light are attractive targets for controlling cellular functions. However, previous approaches have considerable technical limitations related to their use of UV, short-wavelength visible (vis), and infrared (IR) laser light, which have poor penetration into biological tissue. Biological tissue is relatively transparent to light inside the diagnostic window at wavelengths of 650-1,100 nm. Here we present a unique optical biotechnological method using carbon nanohorn (CNH) that transforms energy from diagnostic window laser light to heat to control the expression of various genes. We report that with this method, laser irradiation within the diagnostic window resulted in effective heat generation and thus caused heat shock promoter-mediated gene expression. This study provides an important step forward in the development of light-manipulated gene expression technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.