ArticleProceedings of the National Academy of Sciences of the United States of America2012
Phage-based molecular probes that discriminate force-induced structural states of fibronectin in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- A novel fibronectin-binding peptide reveals dynamic intermediate structures during matrix assembly.Scientific reports · 2025Article
- Strain-dependent glutathionylation of fibronectin fibers impacts mechano-chemical behavior and primes an integrin switch.Nature communications · 2024Article
- Advanced detection of cervical cancer biomarkers using engineered filamentous phage nanofibers.Applied microbiology and biotechnology · 2024Article
- Therapeutic Strategies to Overcome Fibrotic Barriers to Nanomedicine in the Pancreatic Tumor Microenvironment.Cancers · 2023Review
- A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype.Cell discovery · 2022Article
- The cardiac nanoenvironment: form and function at the nanoscale.Biophysical reviews · 2021Review
- Biophysical and epigenetic regulation of cancer stemness, invasiveness and immune action.Current tissue microenvironment reports · 2020Article
- Fibronectin fibers are highly tensed in healthy organs in contrast to tumors and virus-infected lymph nodes.Matrix biology plus · 2020Article
- Extracellular Matrix Structure and Composition in the Early Four-Chambered Embryonic Heart.Cells · 2020Article
- Article
- Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment.Nanoscale · 2019Article
- Fibronectin fiber creep under constant force loading.Acta biomaterialia · 2019Article
- Targeting Biophysical Cues: a Niche Approach to Study, Diagnose, and Treat Cancer.Trends in cancer · 2018Review
- α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site.Molecular biology of the cell · 2017Article
- Detection of an Integrin-Binding Mechanoswitch within Fibronectin during Tissue Formation and Fibrosis.ACS nano · 2017Article
- In vitro selection technologies to enhance biomaterial functionality.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Integrin α3β1 Binding to Fibronectin Is Dependent on the Ninth Type III Repeat.The Journal of biological chemistry · 2015Article
- Utilizing Fibronectin Integrin-Binding Specificity to Control Cellular Responses.Advances in wound care · 2015Review
- Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Heparin-dependent regulation of fibronectin matrix conformation.Matrix biology : journal of the International Society for Matrix Biology · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Applied forces and the biophysical nature of the cellular microenvironment play a central role in determining cellular behavior. Specifically, forces due to cell contraction are transmitted into structural ECM proteins and these forces are presumed to activate integrin "switches." The mechanism of such switches is thought to be the partial unfolding of integrin-binding domains within fibronectin (Fn). However, integrin switches remain largely hypothetical due to a dearth of evidence for their existence, and relevance, in vivo. By using phage display in combination with the controlled deposition and extension of Fn fibers, we report the discovery of peptide-based molecular probes capable of selectively discriminating Fn fibers under different strain states. Importantly, we show that the probes are functional in both in vitro and ex vivo tissue contexts. The development of such tools represents a critical step in establishing the relevance of theoretical mechanotransduction events within the cellular microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.