ArticlePediatrics2012
Clinical research involving children: registration, completeness, and publication.
Article in Pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Time to publication for results of clinical trials.The Cochrane database of systematic reviews · 2024Pooled it
- Biologic disease modifying antirheumatic drugs and Janus kinase inhibitors in paediatric rheumatology - what we know and what we do not know from randomized controlled trials.Pediatric rheumatology online journal · 2021Pooled it
- Randomized controlled trials in children's heart surgery in the 21st century: a systematic review.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2018Pooled it
- A systematic review of the processes used to link clinical trial registrations to their published results.Systematic reviews · 2017Pooled it
- Inadequate use and regulation of interventions against publication bias decreases their effectiveness: a systematic review.Journal of clinical epidemiology · 2015Pooled it
- A systematic review of randomized controlled trials for the prevention of bronchopulmonary dysplasia in infants.Journal of perinatology : official journal of the California Perinatal Association · 2014Pooled it
- Public reporting of clinical trial findings as an ethical responsibility to participants: a qualitative study.BMJ open · 2023Article
- Predicting Publication of Clinical Trials Using Structured and Unstructured Data: Model Development and Validation Study.Journal of medical Internet research · 2022Article
- Article
- Results Reporting and Early Termination of Childhood Obesity Trials Registered on ClinicalTrials.gov.Frontiers in pediatrics · 2022Article
- Comparison of Publication of Pediatric Probiotic vs Antibiotic Trials Registered on ClinicalTrials.gov.JAMA network open · 2021Review
- Using a 3 stage process to create a consumer research contact list in a paediatric health setting: the PARTICIPATE project.Research involvement and engagement · 2021Article
- Congenital heart surgery avidly awaits evidence.Indian journal of thoracic and cardiovascular surgery · 2021Article
- Low dissemination rates, non-transparency of trial premature cessation and late registration in child mental health: observational study of registered interventional trials.European child & adolescent psychiatry · 2020Observational
- Trial registration, publication rate and characteristics in the research field of otology: A cross-sectional study.PloS one · 2019Article
- Enhancing communication and social engagement among clinicians and research teams to improve reliability of research recruitment.BMJ open quality · 2019Article
- Publication of Randomized Clinical Trials in Pediatric Research: A Follow-up Study.JAMA network open · 2018Article
- Tracking the timely dissemination of clinical studies. Characteristics and impact of 10 tracking variables.F1000Research · 2018Article
- Discontinuation and Nonpublication of Randomized Clinical Trials Conducted in Children.Pediatrics · 2016Article
- Publication proportions for registered breast cancer trials: before and following the introduction of the ClinicalTrials.gov results database.Research integrity and peer review · 2016Article
Corrections and comments
- Commented on by
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveEffective health care for children must be based on thorough analyses of the best research evidence. The objective of this study was to examine registration, completeness, and publication of studies involving children.
methodsWe searched the ClinicalTrials.gov registry to identify all closed studies involving children and examined them for completeness and availability of results. We examined publication in peer-reviewed journals for 160 randomly selected National Institutes of Health (NIH)-funded studies from 2000 through 2010 and for 758 randomly selected completed studies.
resultsOf 3428 closed studies involving children identified in ClinicalTrials.gov, 2385 (70%) were completed, 28 (0.8%) suspended, 152 (4.4%) terminated, and 38 (1.1%) withdrawn. The proportion of non-completed studies (terminated and suspended) increased linearly by 186% between 2001 and 2009, from 1.9% to 8.4%. Of the 152 terminated studies, 48 did not report reasons for termination, 21 cited safety concerns, and 83 cited poor recruitment or other administrative reasons. Only 29% of completed studies were published. Publication that did occur was an average of 2 years after study completion. Completed interventional studies were published more often than observational studies. Completed industry-funded studies were published less often than studies funded by the NIH. Registered NIH-funded trials were published more often than unregistered.
conclusionsResults are unavailable for more than half of the studies involving children, revealing a substantial publication bias. Registration and posting of results on ClinicalTrials.gov should be mandatory for all studies involving children.
Indexed as
Identifiers
22529271What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.