GuidelineNeurology2012
Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society.
Guideline in Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 298 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
298 citing papers in PubMed, 11 syntheses or guidelines pooled it, 873 citations in OpenAlex.
- Atogepant for migraine prevention: a meta-analysis of safety and efficacy in adults.Frontiers in neurology · 2024Pooled it
- European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention-part 1: amitriptyline.The journal of headache and pain · 2023Pooled it
- The efficacy and safety of atogepant for the prophylactic treatment of migraine: evidence from randomized controlled trials.The journal of headache and pain · 2022Pooled it
- Efficacy and Safety of Melatonin as Prophylaxis for Migraine in Adults: A Meta-analysis.Journal of oral & facial pain and headache · 2022Pooled it
- Comparative efficacy of acupuncture-related therapy for migraine: A systematic review and network meta-analysis.Frontiers in neurology · 2022Pooled it
- Headache and migraine clinical practice guidelines: a systematic review and assessment of complementary and alternative medicine recommendations.BMC complementary medicine and therapies · 2021Pooled it
- Revealing the Neural Mechanism Underlying the Effects of Acupuncture on Migraine: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- Vitamin D in migraine headache: a comprehensive review on literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- Effects of Anti-Calcitonin Gene-Related Peptide for Migraines: A Systematic Review with Meta-Analysis of Randomized Clinical Trials.International journal of molecular sciences · 2019Pooled it
- European headache federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention.The journal of headache and pain · 2019Guideline
- Beta-blockers for the prevention of headache in adults, a systematic review and meta-analysis.PloS one · 2019Pooled it
- Lacosamide Versus Propranolol in Episodic Migraine, a Randomized Controlled Double-blinded Trial.Molecular neurobiology · 2026Trial
- Trial
- Therapeutic efficacy of nimodipine and topiramate on migraine and vestibular migraine; A prospective multicenter open-label study.PloS one · 2026Trial
- Open-Label Placebos as Adjunct for the Preventive Treatment of Migraine: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Early Improvements With Atogepant for the Preventive Treatment of Migraine: Results From 3 Randomized Phase 3 Trials.Neurology · 2025Trial
- Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics.Frontiers of medicine · 2023Trial
- Erenumab versus topiramate: post hoc efficacy analysis from the HER-MES study.The journal of headache and pain · 2022Trial
- Changes in acute headache medication use and health care resource utilization: Results from a randomized, double-blind, placebo-controlled clinical trial evaluating galcanezumab in adults with treatment-resistant migraine (CONQUER).Journal of managed care & specialty pharmacy · 2022Trial
- Rates of Response to Atogepant for Migraine Prophylaxis Among Adults: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2022Trial
238 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo provide updated evidence-based recommendations for the preventive treatment of migraine headache. The clinical question addressed was: What pharmacologic therapies are proven effective for migraine prevention?
methodsThe authors analyzed published studies from June 1999 to May 2009 using a structured review process to classify the evidence relative to the efficacy of various medications available in the United States for migraine prevention. RESULTS AND RECOMMENDATIONS: The author panel reviewed 284 abstracts, which ultimately yielded 29 Class I or Class II articles that are reviewed herein. Divalproex sodium, sodium valproate, topiramate, metoprolol, propranolol, and timolol are effective for migraine prevention and should be offered to patients with migraine to reduce migraine attack frequency and severity (Level A). Frovatriptan is effective for prevention of menstrual migraine (Level A). Lamotrigine is ineffective for migraine prevention (Level A).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.