Evidence map›Paper›PMID 22528985›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2012

Biomimetic delivery with micro- and nanoparticles.

Stephen C Balmert, Steven R Little

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Review
  2. Article
  3. Controlled Release of Molecules to Enhance Cell Survival and Regeneration.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stephen C BalmertDepartment of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261 USA.
Steven R Little

Funding

University of Pittsburgh Clinical and Translational Science InstitutionKL2RR024154 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$22.2M
University of Pittsburgh Clinical and Translational Science InstitutionKL2TR000146 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$8.7M
Treatment of Periodontitis via Recruitment of Regulatory LymphocytesR01DE021058 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LITTLE, STEVEN R · 2011 to 2015
$1.8M
NCATS NIH HHS KL2 TR000146NCRR NIH HHS 5KL2RR024154 02NCRR NIH HHS K12 RR024154NCRR NIH HHS KL2 RR024154NIDCR NIH HHS 1R01DE021058-01 A1NIDCR NIH HHS R01 DE021058
6 · The paper itself

Abstract

The nascent field of biomimetic delivery with micro- and nanoparticles (MNP) has advanced considerably in recent years. Drawing inspiration from the ways that cells communicate in the body, several different modes of "delivery" (i.e., temporospatial presentation of biological signals) have been investigated in a number of therapeutic contexts. In particular, this review focuses on (1) controlled release formulations that deliver natural soluble factors with physiologically relevant temporal context, (2) presentation of surface-bound ligands to cells, with spatial organization of ligands ranging from isotropic to dynamically anisotropic, and (3) physical properties of particles, including size, shape and mechanical stiffness, which mimic those of natural cells. Importantly, the context provided by multimodal, or multifactor delivery represents a key element of most biomimetic MNP systems, a concept illustrated by an analogy to human interpersonal communication. Regulatory implications of increasingly sophisticated and "cell-like" biomimetic MNP systems are also discussed.

Indexed as

Drug Delivery SystemsAdjuvants, ImmunologicAnimalsAntigen-Presenting CellsArtificial CellsBiomimetic MaterialsChemokinesDelayed-Action PreparationsEndocytosisErythrocytesHumansInflammationLigandsNanocompositesNanoparticlesNanotechnologyAdjuvants, ImmunologicChemokinesDelayed-Action PreparationsLigandsOpsonin Proteins

Identifiers

PMID22528985
PMCPMC3627374

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.