ReviewNeuropsychology review2012
Translational rodent models of Korsakoff syndrome reveal the critical neuroanatomical substrates of memory dysfunction and recovery.
Review in Neuropsychology review, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Neuroprotective Effects of Carnosine Against Corticosterone-Induced Depression and Memory Impairment.Food science & nutrition · 2026Article
- Adolescent Alcohol and the Spectrum of Cognitive Dysfunction in Aging.Advances in experimental medicine and biology · 2025Review
- Distinct Sleep Alterations in Alcohol Use Disorder Patients with and without Korsakoff's Syndrome: Relationship with Episodic Memory.Journal of clinical medicine · 2023Article
- Article
- Neuroinflammation regulates the balance between hippocampal neuron death and neurogenesis in an ex vivo model of thiamine deficiency.Journal of neuroinflammation · 2022Article
- The limbic memory circuit and the neural basis of contextual memory.Neurobiology of learning and memory · 2022Article
- Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function.Neuropsychology review · 2021Review
- Thiamine Deficiency Increases Intrinsic Excitability of Mouse Cerebellar Purkinje Cells.Cerebellum (London, England) · 2021Article
- The Inferior Colliculus in Alcoholism and Beyond.Frontiers in systems neuroscience · 2020Review
- A Pivotal Role for Thiamine Deficiency in the Expression of Neuroinflammation Markers in Models of Alcohol-Related Brain Damage.Alcoholism, clinical and experimental research · 2019Article
- From adolescence to late aging: A comprehensive review of social behavior, alcohol, and neuroinflammation across the lifespan.International review of neurobiology · 2019Review
- Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction.International review of neurobiology · 2019Review
- The Regulatory Role of the Human Mediodorsal Thalamus.Trends in cognitive sciences · 2018Review
- United states of amnesia: rescuing memory loss from diverse conditions.Disease models & mechanisms · 2018Article
- Nerve Growth Factor Is Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function.Frontiers in neuroscience · 2018Article
- Adolescent binge ethanol exposure alters specific forebrain cholinergic cell populations and leads to selective functional deficits in the prefrontal cortex.Neuroscience · 2017Article
- BDNF regains function in hippocampal long-term potentiation deficits caused by diencephalic damage.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Cognitive Decline and Recovery in Alcohol Abuse.Journal of molecular neuroscience : MN · 2016Review
- Exercise leads to the re-emergence of the cholinergic/nestin neuronal phenotype within the medial septum/diagonal band and subsequent rescue of both hippocampal ACh efflux and spatial behavior.Experimental neurology · 2016Article
- Interactions between chronic ethanol consumption and thiamine deficiency on neural plasticity, spatial memory, and cognitive flexibility.Alcoholism, clinical and experimental research · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Investigation of the amnesic disorder Korsakoff Syndrome (KS) has been vital in elucidating the critical brain regions involved in learning and memory. Although the thalamus and mammillary bodies are the primary sites of neuropathology in KS, functional deactivation of the hippocampus and certain cortical regions also contributes to the chronic cognitive dysfunction reported in KS. The rodent pyrithiamine-induced thiamine deficiency (PTD) model has been used to study the extent of hippocampal and cortical neuroadaptations in KS. In the PTD model, the hippocampus, frontal and retrosplenial cortical regions display loss of cholinergic innervation, decreases in behaviorally stimulated acetylcholine release and reductions in neurotrophins. While PTD treatment results in significant impairment in measures of spatial learning and memory, other cognitive processes are left intact and may be recruited to improve cognitive outcome. In addition, behavioral recovery can be stimulated in the PTD model by increasing acetylcholine levels in the medial septum, hippocampus and frontal cortex, but not in the retrosplenial cortex. These data indicate that although the hippocampus and frontal cortex are involved in the pathogenesis of KS, these regions retain neuroplasticity and may be critical targets for improving cognitive outcome in KS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.