ArticleJournal of neuro-oncology2012
Evaluation of brain tumors using dynamic 11C-methionine-PET.
Article in Journal of neuro-oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Neuroradiologic characteristics of astroblastoma and systematic review of the literature: 2 new cases and 125 cases reported in 59 publications.Pediatric radiology · 2016Pooled it
- The Role of 11C-Methionine PET Imaging for the Evaluation of Lymphomas: A Systematic Review.Hematology reports · 2024Review
- Differentiation of astrocytoma between grades II and III using a combination of methionine positron emission tomography and magnetic resonance spectroscopy.World neurosurgery: X · 2023Article
- Methionine metabolism and endocrine function of the pituitary gland in patients with suprasellar germinoma.PloS one · 2023Article
- Selective resection of cushing microadenoma guided by preoperative hybrid 18-fluoroethyl-L-tyrosine and 11-C-methionine PET/MRI.Pituitary · 2021Article
- DynamicCancers · 2021Article
- Validation of PET/MRI attenuation correction methodology in the study of brain tumours.BMC medical imaging · 2020Article
- Preliminary clinical assessment of dynamic carbon-11 methionine positron-emission tomography/computed tomography for the diagnosis of the pathologies in patients with musculoskeletal lesions: a prospective study.European journal of hybrid imaging · 2020Article
- Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Characteristics of time-activity curves obtained from dynamicJournal of neuro-oncology · 2018Article
- Uptake of AV-1451 in meningiomas.Annals of nuclear medicine · 2017Article
- Clinical Utility of Positron Emission Tomography in Patients with Malignant Glioma.Neurologia medico-chirurgica · 2017Review
- Structural Snapshots of an Engineered Cystathionine-γ-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.Biochemistry · 2017Article
- Diagnostic and Prognostic Significance of Methionine Uptake and Methionine Positron Emission Tomography Imaging in Gliomas.Frontiers in oncology · 2017Review
- Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas.Neuro-oncology · 2015Article
- Developing biomarker-specific end points in lung cancer clinical trials.Nature reviews. Clinical oncology · 2015Review
- Bevacizumab treatment leads to observable morphological and metabolic changes in brain radiation necrosis.Journal of neuro-oncology · 2014Article
- Hypofractionated high-dose irradiation with positron emission tomography data for the treatment of glioblastoma multiforme.BioMed research international · 2014Article
- Combination Methionine-methylation-axis Blockade: A Novel Approach to Target the Methionine Addiction of Cancer.Cancer genomics & proteomicsReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is to assess whether dynamic imaging of (11)C-methionine (MET) uptake on positron emission tomography (PET) is useful for the differential diagnosis of brain tumor histology. Regional MET uptake in static brain PET scans from three consecutive phases (5-15, 15-25, and 25-35 min) after intravenous injection were measured in 144 patients with brain tumors. Regions of interest (ROI) were placed in the pituitary gland, confluence, choroid plexus, coronal radiation, brainstem, frontal cortex, parietal cortex, cerebellum, and brain tumors. The standard uptake value (SUV) of the ROIs in the normal brain structures and brain tumors were measured, and the mean MET SUV region/normal frontal lobe cortex uptake ratio (R/N ratio) of the normal brain structures and the maximum MET SUV tumor/normal frontal cortex uptake ratio (T/N ratio) were evaluated semi-quantitatively. There were significant dynamic declines of the mean MET R/N ratio in the normal pituitary gland and confluence; however, there were significant dynamic increases in white matter. Significant dynamic decrease of the maximum MET T/N ratio was seen in meningiomas and oligodendrocytic tumors, whereas significant dynamic increase was seen in glioblastomas and malignant lymphomas. Dynamic changes of MET uptake vary significantly with the normal brain structures and brain tumor histology. These results suggest that MET-PET may be useful in the differential diagnosis of brain tumors.
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Registered trials
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