ArticleJournal of cardiovascular translational research2012
Phenotypic and functional alterations on inflammatory peripheral blood cells after acute myocardial infarction.
Article in Journal of cardiovascular translational research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Targeting the heart-immune axis after myocardial infarction: from inflammation to immunomodulation.Frontiers in cardiovascular medicine · 2026Review
- The sentinels of coronary artery disease: heterogeneous monocytes.Frontiers in immunology · 2025Review
- Role of monocytes and dendritic cells in cardiac reverse remodelling after cardiac resynchronization therapy.BMC cardiovascular disorders · 2023Article
- Reduced numbers of regulatory T cells in chronic heart failure seems not to be restored by cardiac resynchronization therapy.BMC cardiovascular disorders · 2023Article
- Leukocyte-Mediated Cardiac Repair after Myocardial Infarction in Non-Regenerative vs. Regenerative Systems.Journal of cardiovascular development and disease · 2022Review
- Organized Chaos: Deciphering Immune Cell Heterogeneity's Role in Inflammation in the Heart.Biomolecules · 2021Review
- Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity, cardiovascular disease and cancer.Cellular & molecular immunology · 2021Review
- Characterization of dendritic cells in human and experimental myocarditis.ESC heart failure · 2020Article
- Chitosan Hydrogel Enhances the Therapeutic Efficacy of Bone Marrow-Derived Mesenchymal Stem Cells for Myocardial Infarction by Alleviating Vascular Endothelial Cell Pyroptosis.Journal of cardiovascular pharmacology · 2020Article
- Suppression of T cells by mesenchymal and cardiac progenitor cells is partly mediated via extracellular vesicles.Heliyon · 2018Article
- Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies.Journal of immunology research · 2016Review
- Human Bone Marrow-Derived Mesenchymal Stromal Cells Differentially Inhibit Cytokine Production by Peripheral Blood Monocytes Subpopulations and Myeloid Dendritic Cells.Stem cells international · 2015Article
- Transient decrease in human peripheral blood myeloid dendritic cells following influenza vaccination correlates with induction of serum antibody.Immunological investigations · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The frequency and function of T cells, monocytes, and dendritic cell subsets were investigated in 12 patients after acute myocardial infarction (AMI)-(T0), 1 month after the episode (T1), and in 12 healthy individuals (HG). The cell characterization and the functional studies were performed by flow cytometry and by RT-PCR, after cell sorting. The most important findings at T0 moment, when compared with T1 and HG, were: a decrease in the frequency of IL-2-producing T cells; a lower frequency of TNF-α- and IL-6-producing monocytes, myeloid dendritic cells, and CD14(-/low)CD16(+)DCs; and a lower TNF-α mRNA expression, after sorting these cells. Moreover, the regulatory function of Treg cells, at T0 moment, was upregulated, based on the FoxP3, CTLA-4, and TGF-β mRNA expression increase. The majority of these phenotypic and functional alterations disappeared at T1. Our data demonstrate that AMI induces a significant change in the immune system homeostasis.
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Registered trials
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