ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2012
Psychosis from a bath salt product containing flephedrone and MDPV with serum, urine, and product quantification.
Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of synthetic cathinone use and psychosis.Psychopharmacology · 2024Pooled it
- Synthetic Cathinones and Neurotoxicity Risks: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- New Psychoactive Substances and Suicidality: A Systematic Review of the Current Literature.Medicina (Kaunas, Lithuania) · 2021Pooled it
- In pursuit of inter-specialty consensus on excited delirium syndrome: a scoping literature review.Forensic science, medicine, and pathology · 2023Article
- Structure-Activity Relationship ofACS chemical neuroscience · 2023Article
- An updated review on synthetic cathinones.Archives of toxicology · 2021Review
- Toxicological investigations in a death involving 2-MAPB.Forensic science, medicine, and pathology · 2021Article
- Hazard Characterization of Synthetic Cathinones Using Viability, Monoamine Reuptake, and Neuronal Activity Assays.Frontiers in neuroscience · 2020Article
- Fatalities associated with NPS stimulants in the Greater Cologne area.International journal of legal medicine · 2020Article
- Acute and repeated administration of MDPV increases aggressive behavior in mice: forensic implications.International journal of legal medicine · 2019Article
- A case of fatal idiosyncratic reaction to the designer drug 3,4-methylenedioxypyrovalerone (MDPV) and review of the literature.Forensic science, medicine, and pathology · 2017Review
- The Psychoactive Designer Drug and Bath Salt Constituent MDPV Causes Widespread Disruption of Brain Functional Connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Severe Psychosis, Drug Dependence, and Hepatitis C Related to Slamming Mephedrone.Case reports in psychiatry · 2016Article
- The effect of banning MDPV on the incidence of MDPV-positive findings among users of illegal drugs and on court decisions in traffic cases in Finland.International journal of legal medicine · 2015Article
- Acute Methylenedioxypyrovalerone Toxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2015Article
- Synthetic cathinones: a new public health problem.Current neuropharmacology · 2015Review
- 'Designer drugs': update on the management of novel psychoactive substance misuse in the acute care setting.Clinical medicine (London, England) · 2014Review
- Bath salts and synthetic cathinones: an emerging designer drug phenomenon.Life sciences · 2014Review
- Bath salts, mephedrone, and methylenedioxypyrovalerone as emerging illicit drugs that will need targeted therapeutic intervention.Advances in pharmacology (San Diego, Calif.) · 2014Review
- Emerging drugs of abuse: current perspectives on substituted cathinones.Substance abuse and rehabilitation · 2014Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe use of designer drugs commonly marketed as bath salts or plant food has risen dramatically in recent years. Several different synthetic cathinones have been indentified in these products, including mephedrone, 3,4-methylenedioxypyrovalerone (MDPV), and 4-fluoromethcathinone (flephedrone). We report a case of bath salt intoxication with quantitative MDPV and flephedrone levels in a patient's serum and urine, and from the bath salt product. CASE REPORT: A 23-year-old male with a prior psychiatric history arrived via EMS for bizarre behavior, suicidality, and hallucinations after reportedly insufflating a bath salt. He was found to have MDPV levels of 186 and 136 ng/mL in his serum and urine, respectively, and flephedrone levels of 346 and 257 ng/mL in the serum and urine, respectively. The white powder in question was found to contain 143 μg MDPV and 142 μg flephedrone per milligram powder. His psychosis and agitation resolved with lorazepam, droperidol, and observation in the emergency department. DISCUSSION: Agitation, psychosis, movement disorders, tachycardia, and hypertension have all been attributed to the use of MDPV; there are no prior reports detailing clinical experience with flephedrone. Considering that our patient's serum flephedrone levels were twofold higher than his MDPV level, it is likely flephedrone contributed to his clinical toxicity. This case suggests the possibility that fluorinated cathinones, such as flephedrone, may have altered metabolism and/or elimination which may affect their course of clinical toxicity. This case highlights the evolving composition of synthetic cathinones found in bath salt products.
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