ArticleInternational urology and nephrology2013
Relative contributions of inflammation and inadequate protein intake to hypoalbuminemia in patients on maintenance hemodialysis.
Article in International urology and nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- A Machine Learning-Based Prediction Model for Deep Infiltrating Endometriosis.International journal of women's health · 2026Article
- Short-Term Safety of Nutri-Jelly in Adults Undergoing Hemodialysis.Food science & nutrition · 2024Article
- Article
- Intradialytic nutrition and quality of life in Chilean older patients in hemodialysis with protein-energy wasting.International urology and nephrology · 2022Article
- Natural Bioactive Compounds in the Management of Oral Diseases in Nephropathic Patients.International journal of environmental research and public health · 2022Review
- Inflammation and Cardiovascular Disease Associated With Hemodialysis for End-Stage Renal Disease.Frontiers in pharmacology · 2022Review
- Vegetarian diet in dialysis patients: A significant gap between actual intake and current nutritional recommendations.Medicine · 2021Article
- Association of Pre-End-Stage Renal Disease Serum Albumin With Post-End-Stage Renal Disease Outcomes Among Patients Transitioning to Dialysis.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2019Article
- Article
- Long Pentraxin 3 as a Broader Biomarker for Multiple Risk Factors in End-Stage Renal Disease: Association with All-Cause Mortality.Mediators of inflammation · 2019Article
- Serum uric acid, protein intake and mortality in hemodialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Article
- Serum albumin, a good indicator of persistent organ failure in acute pancreatitis.BMC gastroenterology · 2017Article
- Dietary protein intake and chronic kidney disease.Current opinion in clinical nutrition and metabolic care · 2017Review
- Association of dental and periodontal disease with chronic kidney disease in patients of a single, tertiary care centre in Thailand.BMJ open · 2016Article
- North American experience with Low protein diet for Non-dialysis-dependent chronic kidney disease.BMC nephrology · 2016Review
- Hypomagnesemia and Mortality in Incident Hemodialysis Patients.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Observational
- End stage renal disease as a modifier of the periodontal microbiome.BMC nephrology · 2015Article
- Latest consensus and update on protein-energy wasting in chronic kidney disease.Current opinion in clinical nutrition and metabolic care · 2015Review
- Hypoalbuminaemia in haemodialysis patients at Parirenyatwa group of hospitals and Chitungwiza central hospital.The Pan African medical journal · 2015Article
- Peri-aortic fat tissue and malnutrition-inflammation-atherosclerosis/calcification syndrome in end-stage renal disease patients.International urology and nephrology · 2013Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeSerum albumin is one of the strongest mortality predictors in maintenance hemodialysis (MHD) patients. Yet, the degree to which serum albumin represents dietary protein intake or an inflammatory state, among others, is not clear. We hypothesize that these inadequate protein intake and inflammation contribute somewhat equally to hypoalbuminemia.
methodsIn a cross-sectional analysis, we examined correlates of low serum albumin, <3.8 g/dL, in 812 MHD patients in whom interleukin-6 (IL-6) and normalized protein nitrogen appearance (nPNA), also known as normalized protein catabolic rate (nPCR), were also measured. Logistic regression estimated odds ratios were employed, and spline models were plotted to examine the likelihood of relatively low serum albumin <3.8 g/dL.
resultsMean age (±SD) of patients was 54 ± 15 years; 53 % of patients were men, 50 % Hispanic, 31 % African-American, and 55 % diabetic. The mean dialysis vintage was 31 ± 34 months (median: 19, inter-quartile range: 7-44 months). The baseline serum albumin, averaged over a 3-month period (mean ± SD), was 3.88 ± 0.38 g/mL. The unadjusted correlation coefficients of l IL-6 and nPNA with serum albumin were -0.36 and +0.20, respectively (p < 0.001 for each comparison). The likelihood for an albumin <3.8 gr/dL increased linearly with decreasing nPNA and rising serum IL-6. This trend was steeper with increasing serum IL-6 up to a concentration of 30 ng/mL.
conclusionsBoth low protein intakes and a high state of inflammation are associated with low serum albumin in MHD patients.
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