Evidence map›Paper›PMID 22528566›Full record

ArticlePathology oncology research : POR2013

Six cases of rare gene amplifications and multiple copy of fusion gene in childhood acute lymphoblastic leukemia.

Irén Haltrich, Monika Csóka, Gábor Kovács, Dóra Török, Donát Alpár, Gábor Ottoffy, György Fekete

Abstract readCase Reports
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In one paragraph

Article in Pathology oncology research : POR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Coexistence of iAMP21 andMolecular cytogenetics · 2016
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Irén Haltrich2nd Department of Pediatrics, Faculty of Medicine, Semmelweis University, 1094 Budapest, Tűzoltó utca 7-9, Hungary. haltrich.iren@med.semmelweis-univ.hu
Monika Csóka
Gábor Kovács
Dóra Török
Donát Alpár
Gábor Ottoffy
György Fekete
Semmelweis University · HUUniversity of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytogenetic aberrations are very important factors in risk assessment of childhood hematological malignancies. We report six childhood acute lymphoid leukemia (ALL) cases with rare cytogenetic aberrations: five with RUNX1, ABL1 or MLL proto-oncogene amplification and one case of multiple copies of ETV6/RUNX1 fusion genes. The simultaneous presence of two adverse genetic aberrations is of special interest: ETV6-RUNX1 fusion gene is associated with good prognosis and intrachromosomal amplification of the homologue RUNX1 gene is associated with poor prognosis. We also report a patient with MLL amplification, a unique finding in childhood T-ALL. Report of these subtle rearrangements contributes to our understanding of diagnostic and prognostic significance of these rare cytogenetic abnormalities.

Indexed as

Gene AmplificationGene FusionAdolescentChildChild, PreschoolCore Binding Factor Alpha 2 SubunitETS Translocation Variant 6 ProteinFemaleHistone-Lysine N-MethyltransferaseHumansIn Situ Hybridization, FluorescenceMaleMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionPrecursor Cell Lymphoblastic Leukemia-LymphomaProto-Oncogene MasCore Binding Factor Alpha 2 SubunitETS Translocation Variant 6 ProteinHistone-Lysine N-MethyltransferaseKMT2A protein, humanMAS1 protein, humanMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionProto-Oncogene MasProto-Oncogene Proteins c-etsRepressor ProteinsRUNX1 protein, human

Identifiers

PMID22528566
OpenAlexW2044838741

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.