ReviewCurrent atherosclerosis reports2012
The complex genetic basis of plasma triglycerides.
Review in Current atherosclerosis reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Pancreatitis as a Main Consequence ofInternational journal of genomics · 2024Article
- Clinical heterogeneity in monogenic chylomicronaemia.BMJ case reports · 2022Article
- A Compound Heterozygous Mutation of Lipase Maturation Factor 1 is Responsible for Hypertriglyceridemia of a Patient.Journal of atherosclerosis and thrombosis · 2019Article
- Article
- Genetics of Triglycerides and the Risk of Atherosclerosis.Current atherosclerosis reports · 2017Review
- Increased Binding of Apolipoproteins A-I and E4 to Triglyceride-Rich Lipoproteins is linked to Induction of Hypertriglyceridemia.JSM atherosclerosis · 2017Article
- Chylomicronaemia--current diagnosis and future therapies.Nature reviews. Endocrinology · 2015Review
- Binding of human apoA-I[K107del] variant to TG-rich particles: implications for mechanisms underlying hypertriglyceridemia.Journal of lipid research · 2014Article
- Comprehensive evaluation of the association of APOE genetic variation with plasma lipoprotein traits in U.S. whites and African blacks.PloS one · 2014Article
- Demystifying the management of hypertriglyceridaemia.Nature reviews. Cardiology · 2013Review
- Hypertriglyceridemia.Nutrients · 2013Article
- Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia.Journal of lipid research · 2013Article
- Postprandial hypertriglyceridemia and cardiovascular disease: current and future therapies.Current atherosclerosis reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Demonstration of a direct relationship between plasma triglyceride (TG) concentration and atherosclerosis has proven difficult due to confounding variables that accompany elevated plasma TG, such as other dyslipidemias, obesity, and type 2 diabetes. However, human genetic studies have provided evidence suggesting a causal link between plasma TG and cardiovascular risk. Analyses in human patients with hypertriglyceridemia (HTG) also provides insight into the relationship between genetic variation, predisposition to elevated plasma TG, and risk of subsequent cardiovascular disease. Here, we review recent key studies that have contributed to our understanding of the genetic determinants of plasma TG concentration, including HTG susceptibility and phenotypic heterogeneity, and discuss our maturing model of the allelic and phenotypic spectrum of plasma TG.
Indexed as
Identifiers
22528520What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.