ArticleJournal of neurovirology2012
Neuroimaging markers of human immunodeficiency virus infection in South Africa.
Article in Journal of neurovirology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus.Purinergic signalling · 2021Review
- Rates of cognitive impairment in a South African cohort of people with HIV: variation by definitional criteria and lack of association with neuroimaging biomarkers.Journal of neurovirology · 2021Article
- Cerebral alterations in West African HIV and non-HIV adults aged ≥50: An MRI study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
- Deep Phenotyping of HIV Neurocognitive Complications Among Individuals Residing in High-Income Countries.Current topics in behavioral neurosciences · 2021Article
- Sensitivity of ventrolateral posterior thalamic nucleus to back pain in alcoholism and CD4 nadir in HIV.Human brain mapping · 2020Article
- Systemic Mitochondrial Oxidative Phosphorylation Protein Levels Correlate with Neuroimaging Measures in Chronically HIV-Infected Individuals.AIDS research and human retroviruses · 2020Article
- Article
- White matter fiber bundle lengths are shorter in cART naive HIV: an analysis of quantitative diffusion tractography in South Africa.Brain imaging and behavior · 2018Article
- The Aging Brain With HIV Infection: Effects of Alcoholism or Hepatitis C Comorbidity.Frontiers in aging neuroscience · 2018Review
- Resting-state functional magnetic resonance imaging in clade C HIV: within-group association with neurocognitive function.Journal of neurovirology · 2017Article
- Neuroimaging abnormalities in clade C HIV are independent of Tat genetic diversity.Journal of neurovirology · 2017Article
- Topological Organization of Whole-Brain White Matter in HIV Infection.Brain connectivity · 2017Article
- Larger Subcortical Gray Matter Structures and Smaller Corpora Callosa at Age 5 Years in HIV Infected Children on Early ART.Frontiers in neuroanatomy · 2017Article
- Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals.Journal of neurovirology · 2016Article
- Prefrontal cortical thinning in HIV infection is associated with impaired striatal functioning.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Human immunodeficiency virus has similar effects on brain volumetrics and cognition in males and females.Journal of neurovirology · 2016Article
- The Effect of Central Nervous System Penetration Effectiveness of Highly Active Antiretroviral Therapy on Neuropsychological Performance and Neuroimaging in HIV Infected Individuals.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015Article
- Association between brain volumes and HAND in cART-naïve HIV+ individuals from Thailand.Journal of neurovirology · 2015Article
- Impact of the HIV Tat C30C31S dicysteine substitution on neuropsychological function in patients with clade C disease.Journal of neurovirology · 2014Article
- Neuroimaging of HIV-associated neurocognitive disorders (HAND).Current opinion in HIV and AIDS · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Previous studies have reported cognitive deficits among HIV-positive individuals infected with clade C virus. However, no study has examined whether individuals predominately infected with clade C virus exhibit brain atrophy relative to healthy controls. This study examined volumetric differences between 28 HIV+ individuals and 23 HIV- controls from South Africa. Volumetric measures were obtained from six regions of interest -- caudate, thalamus, corpus callosum, total cortex, total gray matter, and total white matter. HIV+ participants had significantly lower volumes in the total white matter (p<0.01), thalamus (p<0.01) and total gray matter (inclusive of cortical and subcortical regions, p<0.01). This study is the first to provide evidence of brain atrophy among HIV+ individuals in South Africa, where HIV clade C predominates. Additional research that integrates neuroimaging, comprehensive neuropsychological testing, genetic variance in clade-specific proteins, and the impact of treatment with Antiretrovirals (ARV) are necessary to understand the development of HIV-related neurocognitive disorders in South Africa.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.