ArticleClinical orthopaedics and related research2012
Adult stem cell mobilization enhances intramembranous bone regeneration: a pilot study.
Article in Clinical orthopaedics and related research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- CXCR4 Antagonism to Treat Delayed Fracture Healing.Tissue engineering. Part A · 2019Article
- Strontium ranelate stimulates trabecular bone formation in a rat tibial bone defect healing process.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Intramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models.BoneKEy reports · 2016Article
- BMP2 Regulation of CXCL12 Cellular, Temporal, and Spatial Expression is Essential During Fracture Repair.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Mobilization of endogenous stem cell populations enhances fracture healing in a murine femoral fracture model.Cytotherapy · 2013Article
- CXCL12/CXCR4 signaling and other recruitment and homing pathways in fracture repair.BoneKEy reports · 2013Article
- Mobilization, Isolation and Characterization of Stem Cells from Peripheral Blood: a Systematic Review.Journal of oral & maxillofacial researchReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundStem cell mobilization, which is defined as the forced egress of stem cells from the bone marrow to the peripheral blood (PB) using chemokine receptor agonists, is an emerging concept for enhancing tissue regeneration. However, the effect of stem cell mobilization by a single injection of the C-X-C chemokine receptor type 4 (CXCR4) antagonist AMD3100 on intramembranous bone regeneration is unclear. QUESTIONS/PURPOSES: We therefore asked: Does AMD3100 mobilize adult stem cells in C57BL/6 mice? Are stem cells mobilized to the PB after marrow ablation? And does AMD3100 enhance bone regeneration?
methodsFemale C57BL/6 mice underwent femoral marrow ablation surgery alone (n = 25), systemic injection of AMD3100 alone (n = 15), or surgery plus AMD3100 (n = 57). We used colony-forming unit assays, flow cytometry, and micro-CT to investigate mobilization of mesenchymal stem cells, endothelial progenitor cells, and hematopoietic stem cells to the PB and bone regeneration.
resultsAMD3100 induced mobilization of stem cells to the PB, resulting in a 40-fold increase in mesenchymal stem cells. The marrow ablation injury mobilized all three cell types to the PB over time. Administration of AMD3100 led to a 60% increase in bone regeneration at Day 21.
conclusionsA single injection of a CXCR4 antagonist lead to stem cell mobilization and enhanced bone volume in the mouse marrow ablation model of intramembranous bone regeneration.
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