ArticleFolia microbiologica2012
The antimicrobial action of chitosan, low molar mass chitosan, and chitooligosaccharides on human colonic bacteria.
Article in Folia microbiologica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- Alterations in ileal mucosa bacteria related to diet complexity and growth performance in young pigs.PloS one · 2014Trial
- Functionalized polysaccharides for infection-resistant and regenerative therapies in gynecology.International journal of pharmaceutics: X · 2026Review
- Biodegradable HPMC-chitosan film for moisture retention and quality preservation in fresh-cut mango.Journal of the science of food and agriculture · 2026Article
- Gold Nanoparticles and Chitosan as Innovative Compounds in Medicine and Cosmetology: A Review of Current Applications.Current medicinal chemistry · 2026Review
- Advancements in application of chitosan and cyclodextrins in biomedicine and pharmaceutics: recent progress and future trends.RSC advances · 2024Review
- Chitinase-Assisted Bioconversion of Chitinous Waste for Development of Value-Added Chito-Oligosaccharides Products.Biology · 2023Review
- Assessment of the Antibiofilm Performance of Chitosan-Based Surfaces in Marine Environments.International journal of molecular sciences · 2022Article
- Article
- Effects of Different Oligosaccharides on Growth Performance and Intestinal Function in Broilers.Frontiers in veterinary science · 2022Article
- Antimicrobial Properties of Chitosan and Chitosan Derivatives in the Treatment of Enteric Infections.Molecules (Basel, Switzerland) · 2021Review
- Chitosan: An Overview of Its Properties and Applications.Polymers · 2021Review
- Underscoring the immense potential of chitosan in fighting a wide spectrum of viruses: A plausible molecule against SARS-CoV-2?International journal of biological macromolecules · 2021Review
- Preparation of the Hybrids of Hydrotalcites and Chitosan by Urea Method and Their Antimicrobial Activities.Polymers · 2019Article
- Gut microbiota and diet in patients with different glucose tolerance.Endocrine connections · 2016Article
- Chitosan coating to enhance the therapeutic efficacy of calcium sulfate-based antibiotic therapy in the treatment of chronic osteomyelitis.Journal of biomaterials applications · 2014Article
- Ecological modeling from time-series inference: insight into dynamics and stability of intestinal microbiota.PLoS computational biology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibacterial effect of chitooligosaccharides (COS) and low molar mass chitosans (LMWC) is considered as one of the most important characteristics of chitosan (CS) hydrolysates. Here, we show the in vitro effect of different COS, LMWC, and CS on representative anaerobic bacteria isolated from human colon as a possibility of targeting modification of colonic microflora composition by supplementation of dietary CS products by humans. Specific growth rate of seven selected nonpathogenic anaerobic bacterial strains (Clostridium paraputrificum, Clostridium beijerinckii, Roseburia intestinalis, Bacteroides vulgatus, Bacteriodes thetaiotaomicron, Faecalibacterium prausnitzii and Blautia coccoides) was determined in the presence of 0.25 and 0.5% COS (2, 3, and 6 kDa), 0.025 and 0.05% of LMWC (10 and 16 kDa), and 0.025 and 0.1% of CS in vitro. The growth rate decreased in all strains in the presence of COS and LMWC in higher concentrations in comparison to control incubations. A relatively higher resistance to CS hydrolyzates was detected in R. intestinalis and F. prausnitzii, and more susceptible were bacteria belonging to Bacteoides sp. and Clostridium sp. The antimicrobial activity, minimum inhibitory concentrations (MIC), and minimal bactericidal concentrations (MBC) were determined. The antimicrobial activity increased with the degree of polymerization (DP). MIC ranged from 0.25 to 4.5% in dependence on bacterial strain and DP of CS/LMWC. MBC also decreased with DP. The most effective antimicrobial action was detected in LMWC with 16 kDa and CS. Weak antimicrobial activity was found in COS with small molecules (2 and 3 kDa).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.