ReviewImmunologic research2012
Regulation of T helper cell differentiation by interferon regulatory factor family members.
Review in Immunologic research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Chicken IRF10 suppresses the cGAS-STING-IFN antiviral signaling pathway by targeting IRF7.Frontiers in immunology · 2026Article
- Unveiling regulatory variants in the blood transcriptome and their association with immunity traits in pigs.Frontiers in immunology · 2025Article
- SARS-CoV-2 inflammation durably imprints memory CD4 T cells.Science immunology · 2024Article
- Inflammation durably imprints memory CD4+ T cells.bioRxiv : the preprint server for biology · 2023Article
- PLP2 Could Be a Prognostic Biomarker and Potential Treatment Target in Glioblastoma Multiforme.Pharmacogenomics and personalized medicine · 2023Article
- Hypomethylated interferon regulatory factor 8 recruits activating protein-2α to attenuate porcine epidemic diarrhea virus infection in porcine jejunum.Frontiers in immunology · 2023Article
- Molecular identification and functional characterization of IRF4 from common carp (Cyprinus carpio. L) in immune response: a negative regulator in the IFN and NF-κB signalling pathways.BMC veterinary research · 2022Article
- IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer.Journal of translational medicine · 2022Article
- Interferon Regulatory Factor Family Genes: At the Crossroads between Immunity and Head and Neck Squamous Carcinoma.Disease markers · 2022Article
- Interferon regulatory factor family influences tumor immunity and prognosis of patients with colorectal cancer.Journal of translational medicine · 2021Article
- Evolution of the IRF Family in Salmonids.Genes · 2021Article
- Uncovering Sub-Structure and Genomic Profiles in Across-Countries Subpopulations of Angus Cattle.Scientific reports · 2020Article
- IRF-2 Inhibits Gastric Cancer Invasion and Migration by Down-Regulating MMP-1.Digestive diseases and sciences · 2020Article
- T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation.Journal of autoimmunity · 2019Article
- Interferon regulatory factor 7 functions as a novel negative regulator of pathological cardiac hypertrophy.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Expression profiling of lymph node cells from deer mice infected with Andes virus.BMC immunology · 2013Article
- MR1 overexpression correlates with poor clinical prognosis in glioma patients.Neuro-oncology advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Interferon regulatory factors (IRFs) consist of a family of transcription factors with diverse functions in the transcriptional regulation of cellular responses in health and diseases. IRFs commonly contain a DNA-binding domain in the N-terminus, with most members also containing a C-terminal IRF-associated domain that mediates protein-protein interactions. Ten IRFs and several virus-encoded IRF homologs have been identified in mammals so far. In response to endogenous and microbial stimuli during an immune response, IRFs are activated, and selectively and cooperatively modulate the expression of key cytokine and transcription factors involved in T helper cell differentiation in T cells and/or antigen-presenting cells. This review focuses on recent advances in the understanding of IRF-mediated transcriptional regulation in T helper cell differentiation and discusses the implications on the development of cellular and humoral immune responses and the pathogenesis of immune disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.