ArticleMetabolic brain disease2012
Early maternal separation leads to down-regulation of cytokine gene expression.
Article in Metabolic brain disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed.
- Environmental enrichment as an intervention to prevent behavioral and neurobiological consequences of maternal separation in rodents: a scope review.Neurobiology of stress · 2026Article
- Understanding Role of Maternal Separation in Depression, Anxiety,and Pain Behaviour: A Mini Review of Preclinical Research With Focus on Neuroinflammatory Pathways.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025Review
- At the Crossroad Between Resiliency and Fragility: A Neurodevelopmental Perspective on Early-Life Experiences.Frontiers in cellular neuroscience · 2022Review
- Article
- Enduring neuroimmunological consequences of developmental experiences: From vulnerability to resilience.Molecular and cellular neurosciences · 2020Review
- Stress, alcohol and infection during early development: A brief review of common outcomes and mechanisms.Journal of neuroendocrinology · 2018Review
- Article
- Effects of early-life adversity on immune function are mediated by prenatal environment: Role of prenatal alcohol exposure.Brain, behavior, and immunity · 2017Article
- Cognitive impairment effects of early life stress in adolescents can be predicted with early biomarkers: Impacts of sex, experience, and cytokines.Psychoneuroendocrinology · 2016Article
- Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity.Developmental cognitive neuroscience · 2015Article
- Analysis of chemokines and receptors expression profile in the myelin mutant taiep rat.Oxidative medicine and cellular longevity · 2015Article
- Vaginal hypersensitivity and hypothalamic-pituitary-adrenal axis dysfunction as a result of neonatal maternal separation in female mice.Neuroscience · 2014Article
- The behavioral and immunological impact of maternal separation: a matter of timing.Frontiers in behavioral neuroscience · 2014Article
- The interplay of early-life stress, nutrition, and immune activation programs adult hippocampal structure and function.Frontiers in molecular neuroscience · 2014Review
- Rodent models of depression: neurotrophic and neuroinflammatory biomarkers.BioMed research international · 2014Review
- Early-life stress and inflammation: A systematic review of a key experimental approach in rodents.Brain and neuroscience advancesReview
- Neuroimmunological effects of early life experiences.Brain and neuroscience advancesReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to stressors may lead to subsequent alterations in the immune response. The precise mechanisms underlying such vulnerability are poorly understood, but may be hypothesized to include changes in cytokine systems. Maternal separation was used as a model of exposure to early life stressors. Subsequent cytokine gene expression was studied using a cytokine gene expression array. Maternal separation resulted in significant down-regulation of the expression of 6 cytokine genes; chemokine ligand 7, chemokine receptor 4, interleukin 10, interleukin-1beta, interleukin 5 receptor alpha and integrin alpha M. Specific cytokines may be involved in mediating the effects of early adversity on subsequent immunosuppression. Further work is needed to delineate fully the relationship between early adversity, immune alterations, and behavioural changes.
Indexed as
Identifiers
22527996What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.