ArticleReproductive sciences (Thousand Oaks, Calif.)2012
Stress exacerbates endometriosis manifestations and inflammatory parameters in an animal model.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models.Molecular human reproduction · 2025Pooled it
- Prolactin and pain of endometriosis.Pharmacology & therapeutics · 2023Pooled it
- A systematic review and meta-analysis on alcohol consumption and risk of endometriosis: an update from 2012.Scientific reports · 2022Pooled it
- Endometriosis patients in the postmenopausal period: pre- and postmenopausal factors influencing postmenopausal health.BioMed research international · 2014Trial
- Predictive markers of endometriosis: a future perspective.Archives of gynecology and obstetrics · 2026Review
- Association of body mass index on sexual function in women with endometriosis: A cross-sectional study.PloS one · 2026Article
- Causal Association Between Sleep Traits and Endometriosis: A Mendelian Randomization Study.International journal of women's health · 2026Article
- Review
- Implication of the enteric glia in the IBS-like colonic inflammation associated with endometriosis.BMC women's health · 2024Article
- Endometriosis, Pain, and Related Psychological Disorders: Unveiling the Interplay among the Microbiome, Inflammation, and Oxidative Stress as a Common Thread.International journal of molecular sciences · 2024Review
- Mood disorders influencing endometriosis and adenomyosis: Mendelian randomisation study.BJPsych open · 2024Article
- Chronic Stress Blocks the Endometriosis Immune Response by Metabolic Reprogramming.International journal of molecular sciences · 2023Article
- Association between endometriosis and sexual satisfaction among a sample of lebanese women.BMC women's health · 2023Article
- Efficacy of an environmental enrichment intervention for endometriosis: a pilot study.Frontiers in psychology · 2023Article
- Article
- Feasibility and acceptability of an adapted environmental enrichment intervention for endometriosis: A pilot study.Frontiers in global women's health · 2022Article
- Immune micro-environment and drug analysis of peritoneal endometriosis based on epithelial-mesenchymal transition classification.Frontiers in endocrinology · 2022Article
- Lifestyle modifications after the diagnosis of gynecological cancer.BMC women's health · 2021Article
- The Importance of a Multi-Disciplinary Approach to the Endometriotic Patients: The Relationship between Endometriosis and Psychic Vulnerability.Journal of clinical medicine · 2021Review
- Metabolomics in endometriosis: challenges and perspectives for future studies.Reproduction & fertility · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Women with endometriosis have significant emotional distress; however, the contribution of stress to the pathophysiology of this disease is unclear. We used a rat model of endometriosis to examine the effects of stress on the development of this condition and its influence on inflammatory parameters. Female Sprague-Dawley rats were subjected to swim stress for 10 consecutive days prior to the surgical induction of endometriosis by suturing uterine horn implants next to the intestinal mesentery (endo-stress). Sham-stress animals had sutures only, and an endo-no stress group was not subjected to the stress protocol. At the time of sacrifice on day 60, endometriotic vesicles were measured and colons assessed for macroscopic and microscopic damage. Colonic tissue and peritoneal fluid were collected for inflammatory cell analysis. Endometriosis, regardless of stress, produced a decrease in central corticotropin-releasing factor immunoreactivity, specifically in the CA3 subregion of the hippocampus. Prior exposure to stress increased both the number and severity of vesicles found in animals with endometriosis. Stress also increased colonic inflammation, motility, myeloperoxidase levels, and numbers of mast cells. In summary, prior stress may contribute to the development and severity of endometriosis in this animal model through mechanisms involving cell recruitment (eg, mast cells), release of inflammatory mediators, and deregulation of hypothalamic-pituitary axis responses in the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.