Trial reportJournal of assisted reproduction and genetics2012
Hyaluronan-enriched transfer medium improves outcome in patients with multiple embryo transfer failures.
Trial report in Journal of assisted reproduction and genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Hyaluronic Acid Enriched Medium for Embryo Transfer: A Systematic Review and Meta-analysis.JBRA assisted reproduction · 2026Pooled it
- Hyaluronic acid in embryo transfer media for assisted reproductive technologies.The Cochrane database of systematic reviews · 2020Pooled it
- Adherence compounds in embryo transfer media for assisted reproductive technologies.The Cochrane database of systematic reviews · 2014Pooled it
- Effects of Fibroid Size and Hyaluronan-Enriched Transfer Medium on Clinical Pregnancy and Live Birth: A Retrospective Study.Journal of clinical medicine · 2026Article
- Association Study of Hyaluronan-Binding Protein 2 (International journal of molecular sciences · 2025Article
- Hyaluronic Acid in Female Reproductive Health: Tailoring Molecular Weight to Clinical Needs in Obstetric and Gynecological Fields.Pharmaceutics · 2025Review
- Hyaluronan-enriched transfer medium (HETM) can improve the implantation rate in morphologically poor euploid blastocyst transfer.Archives of gynecology and obstetrics · 2023Article
- Effect of hyaluronic acid-enriched transfer medium on frozen-thawed embryo transfer outcomes in RIF patients: a single-centre retrospective study.Frontiers in endocrinology · 2023Article
- A comparison of the clinical effects of thinning and drilling on laser-assisted hatching.Lasers in medical science · 2022Review
- Clinical efficacy of hyaluronate-containing embryo transfer medium in IVF/ICSI treatment cycles: a cohort study.Human reproduction open · 2021Article
- Clinical strategies for ART treatment of infertile women with advanced maternal age.Reproductive medicine and biology · 2019Review
- Clinical outcomes of assisted reproductive technology treatment by using a self-injection of recombinant human chorionic gonadotropin as the final maturation trigger.Reproductive medicine and biology · 2018Article
- Alginate membranes loaded with hyaluronic acid and silver nanoparticles to foster tissue healing and to control bacterial contamination of non-healing wounds.Journal of materials science. Materials in medicine · 2018Article
- Cytokines, growth factors and macromolecules as mediators of implantation in mammalian species.International journal of veterinary science and medicine · 2018Review
- Efficacy of hyaluronan-rich transfer medium on implantation and pregnancy rates in fresh and frozen-thawed blastocyst transfers in Korean women with previous implantation failure.Obstetrics & gynecology science · 2016Article
- Clomiphene citrate affects the receptivity of the uterine endometrium.Reproductive medicine and biology · 2015Article
- Using a mild stimulation protocol combined with clomiphene citrate and recombinant follicle-stimulating hormone to determine the optimal number of oocytes needed to achieve pregnancy and reduce the concerns of patients.Reproductive medicine and biology · 2013Article
- Hyaluronan-CD44 interaction promotes growth of decidual stromal cells in human first-trimester pregnancy.PloS one · 2013Article
- Efficacy of Hyaluronan-Enriched Transfer Medium in Frozen-Thawed Embryo Transfer: A Retrospective Single-Center University Hospital Study Using a Historical Cohort.Reproductive medicine and biologyArticle
- The Effect of a Newly Designed Needle on the Pain and Bleeding of Patients During Oocyte Retrieval of a Single Follicle.Journal of reproduction & infertilityArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo ascertain whether the use of hyaluronan-enriched transfer medium (HETM) improves pregnancy and implantation rates among embryo transfer patients with a history of multiple implantation failures.
methodsPatients (n = 314) under the age of 40 and with a history of multiple unsuccessful embryo transfers were enrolled. There were three groups of patients: those undergoing fresh embryo transfer (fresh ET [n = 111]), those undergoing vitrified-warmed ET in the natural cycle (WET-N [n = 101]) and those undergoing WET in a hormone replacement cycle (WET-H [n = 102]). On the day of ET, patients were randomized to HETM (0.5 mg/ml hyaluronan) or control medium containing no hyaluronan. Only patients with good quality embryos on day 3 were included.
resultsFor all three patients groups (fresh ET, WET-N and WET-H) pregnancy rates (37.5 %, 31.4 % and 41.2 %, respectively) were significantly higher when using HETM compared with control medium (10.9 %, 10.0 % and 15.7 %, respectively; p < 0.05), and implantation rates when using HETM were also significantly higher compared with control medium (p < 0.05). Miscarriage rates were similar in both groups.
conclusionHETM significantly increased pregnancy and implantation rates among embryo transfer patients with a history of multiple unsuccessful implantations-regardless of method used to prepare the endometrium.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.