ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2012
Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Feasibility and operator variability of myocardial blood flow and reserve measurements with ⁹⁹mTc-sestamibi quantitative dynamic SPECT/CT imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Trial
- Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with ¹⁵O-H₂O PET.European radiology · 2014Trial
- Estimation of renal perfusion based on measurement of rubidium-82 clearance by PET/CT scanning in healthy subjects.EJNMMI physics · 2021Article
- Quantification of myocardial blood flow withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- PET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease.EJNMMI research · 2017Article
- Optimally Repeatable Kinetic Model Variant for Myocardial Blood Flow Measurements withComputational and mathematical methods in medicine · 2017Article
- Quantification of myocardial blood flow with (82)Rb: Validation with (15)O-water using time-of-flight and point-spread-function modeling.EJNMMI research · 2016Article
- Current status of nuclear cardiology in Japan: Ongoing efforts to improve clinical standards and to establish evidence.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- Quantification of myocardial blood flow in absolute terms using (82)Rb PET imaging: the RUBY-10 Study.JACC. Cardiovascular imaging · 2014Article
- Time-efficient myocardial contrast partition coefficient measurement from early enhancement with magnetic resonance imaging.PloS one · 2014Article
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11 authors.
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Abstract
purposeMyocardial blood flow (MBF) estimation with (82)Rubidium ((82)Rb) positron emission tomography (PET) is technically difficult because of the high spillover between regions of interest, especially due to the long positron range. We sought to develop a new algorithm to reduce the spillover in image-derived blood activity curves, using non-uniform weighted least-squares fitting.
methodsFourteen volunteers underwent imaging with both 3-dimensional (3D) (82)Rb and (15)O-water PET at rest and during pharmacological stress. Whole left ventricular (LV) (82)Rb MBF was estimated using a one-compartment model, including a myocardium-to-blood spillover correction to estimate the corresponding blood input function Ca(t)(whole). Regional K1 values were calculated using this uniform global input function, which simplifies equations and enables robust estimation of MBF. To assess the robustness of the modified algorithm, inter-operator repeatability of 3D (82)Rb MBF was compared with a previously established method.
resultsWhole LV correlation of (82)Rb MBF with (15)O-water MBF was better (P < .01) with the modified spillover correction method (r = 0.92 vs r = 0.60). The modified method also yielded significantly improved inter-operator repeatability of regional MBF quantification (r = 0.89) versus the established method (r = 0.82) (P < .01).
conclusionA uniform global input function can suppress LV spillover into the image-derived blood input function, resulting in improved precision for MBF quantification with 3D (82)Rb PET.
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