ArticleEuropean journal of pediatrics2012
Factors influencing neurological outcome of children with bacterial meningitis at the emergency department.
Article in European journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Early vs. delayed empiric antimicrobial treatment for suspected acute meningitis - a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Risk factors associated with the outcomes of pediatric bacterial meningitis: a systematic review.Jornal de pediatriaPooled it
- The Role of Fundoscopy Before Lumbar Puncture in Children with Suspected Meningitis.European journal of pediatrics · 2025Article
- The Association Between Elevated Estimated Glomerular Filtration Rate and Poor Clinical Outcomes of Pediatric Patients with Community-Acquired Bacterial Meningitis Receiving Vancomycin: A Ten-Year Retrospective Cohort Study.Infectious diseases and therapy · 2025Article
- Article
- An open window: the crucial role of the gut-brain axis in neurodevelopmental outcomes post-neurocritical illness.Frontiers in pediatrics · 2024Article
- Adding heart rate n-variability (HRnV) to clinical assessment potentially improves prediction of serious bacterial infections in young febrile infants at the emergency department: a prospective observational study.Annals of translational medicine · 2023Article
- Long-term impact of invasive meningococcal disease in children: SEINE study protocol.PloS one · 2022Article
- Cerebrospinal fluid culture-positive bacterial meningitis increases the risk for neurologic damage among neonates.Annals of medicine · 2021Article
- Cerebroprotective Effects of 2-Ethyl-6-methyl-3-hydroxypyridine-2,6-dichlorophenyl(amino)phenylethanoic Acid in the Treatment of Purulent Meningitis.Biomedicines · 2021Article
- S1 guidelines "lumbar puncture and cerebrospinal fluid analysis" (abridged and translated version).Neurological research and practice · 2020Article
- Neurological Complications in Young Infants With Acute Bacterial Meningitis.Frontiers in neurology · 2018Article
- Correlation between CD64 and PCT levels in cerebrospinal fluid and degree of hearing impairment sequelae in neonates with purulent meningitis.Experimental and therapeutic medicine · 2017Article
- Clinical Prognosis in Neonatal Bacterial Meningitis: The Role of Cerebrospinal Fluid Protein.PloS one · 2015Article
- Construction and evaluation of a diagnostic prediction model for bacterial meningitis based on clinical and laboratory data.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
21 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed a cohort study of children who survived bacterial meningitis after the neonatal period at a single pediatric center in France over a 10-year period (1995-2004) to identify predictors of death and long-term neurological deficits in children with bacterial meningitis. We performed multivariate regression to determine independent predictors of death and neurologic deficits. We identified 101 children with bacterial meningitis of which 19 died during initial hospitalization. Need for mechanical ventilation [hazard ratio (HR) 11.5, 95 % confidence interval (CI) 2.4-55.5)] and thrombocytopenia defined as a platelet count <150 × 10(9) per liter (HR 0.6, 95 % CI 0.4-0.9) at presentation were associated with death during initial hospitalization. At final assessment, 42 of the 70 survivors had no neurologic deficits identified; 20 had a single deficit, and eight had multiple deficits. A delay in initiation of antibiotics (HR 1.3, 95 % CI 1.1-1.7) and hydrocephalus on computed tomographic scan (HR 2.6, 95 % CI 1.1-6.0) were associated with having one or more long-term neurologic deficits. Identification of children at risk of death or long-term neurologic sequelae may allow therapeutic interventions to be directed to children at the highest risk.
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