Trial reportEuropean radiology2012
DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study.
Trial report in European radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Radiobiological risks following dentomaxillofacial imaging: should we be concerned?Dento maxillo facial radiology · 2021Review
- The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation Exposure in Interventional Cardiology.Frontiers in public health · 2021Article
- Using radiation safely in cardiology: what imagers need to know.Heart (British Cardiac Society) · 2019Article
- Changes in the Selected Antioxidant Defense Parameters in the Blood of Patients after High Resolution Computed Tomography.International journal of environmental research and public health · 2019Article
- DNA double-strand breaks in blood lymphocytes induced by two-dayEuropean radiology · 2018Article
- Estimation of the effects of medical diagnostic radiation exposure based on DNA damage.Journal of radiation research · 2018Review
- Evaluation of Ameliorative Potential of Vitamins E and C on DNA Double Strand Break (DSB) in Patients Undergoing Computed Tomography (CT): A Clinical Study.International journal of molecular and cellular medicine · 2018Article
- Enhanced radiation dose and DNA damage associated with iodinated contrast media in diagnostic X-ray imaging.The British journal of radiology · 2017Review
- DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters.European radiology · 2017Article
- Celecoxib mitigates genotoxicity induced by ionizing radiation in human blood lymphocytes.Research in pharmaceutical sciences · 2017Article
- Analysis of chromosome translocation frequency after a single CT scan in adults.Journal of radiation research · 2016Article
- Latest-generation catheterization systems enable invasive submillisievert coronary angiography.Herz · 2015Article
- Article
- γ-H2AX foci as in vivo effect biomarker in children emphasize the importance to minimize x-ray doses in paediatric CT imaging.European radiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo prospectively compare induced DNA double-strand breaks by cardiac computed tomography (CT) and conventional coronary angiography (CCA).
methods56 patients with suspected coronary artery disease were randomised to undergo either CCA or cardiac CT. DNA double-strand breaks were assessed in fluorescence microscopy of blood lymphocytes as indicators of the biological effects of radiation exposure. Radiation doses were estimated using dose-length product (DLP) and dose-area product (DAP) with conversion factors for CT and CCA, respectively.
resultsOn average there were 0.12 ± 0.06 induced double-strand breaks per lymphocyte for CT and 0.29 ± 0.18 for diagnostic CCA (P < 0.001). This relative biological effect of ionising radiation from CCA was 1.9 times higher (P < 0.001) than the effective dose estimated by conversion factors would have suggested. The correlation between the biological effects and the estimated radiation doses was excellent for CT (r = 0.951, P < 0.001) and moderate to good for CCA (r = 0.862, P < 0.001). One day after radiation, a complete repair of double-strand breaks to background levels was found in both groups.
conclusionsConversion factors may underestimate the relative biological effects of ionising radiation from CCA. DNA double-strand break assessment may provide a strategy for individualised assessments of radiation. KEY POINTS: • Radiation dose causes concern for both conventional coronary angiography and cardiac CT. • Estimations of the biological effects of ionising radiation may become feasible. • Fewer DNA double-strand breaks are induced by cardiac CT than CCA. • Conversion factors may underestimate the relative effects of ionising radiation from CCA.
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