ArticleEuropean journal of clinical pharmacology2012
Non-steroidal anti-inflammatory drugs (NSAIDs) and hypertension treatment intensification: a population-based cohort study.
Article in European journal of clinical pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- A study of demographic and clinical characteristics of consumers of non-steroidal anti-inflammatory drugs: a large population-based study utilizing enrollment phase data from the tabari cohort.BMC public health · 2025Article
- Potentially harmful drug-drug interactions in the therapeutic regimens of persons with spinal cord injury.The journal of spinal cord medicine · 2024Observational
- Impact of ACEIs and ARBs-related adverse drug reaction on patients' clinical outcomes: a cohort study in UK primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
- Prevalence of non-steroidal anti-inflammatory drugs (NSAIDs) use in patients with hypertensive crisis.Health science reports · 2022Article
- Comparisons of disease cluster patterns, prevalence and health factors in the USA, Canada, England and Ireland.BMC public health · 2021Article
- Hypertension and Prohypertensive Antineoplastic Therapies in Cancer Patients.Circulation research · 2021Review
- Gaseous Mediators as a Key Molecular Targets for the Development of Gastrointestinal-Safe Anti-Inflammatory Pharmacology.Frontiers in pharmacology · 2021Review
- Updated information on new coronavirus disease 2019 occurrence, drugs, and prediction of a potential receptor.Journal of biochemical and molecular toxicology · 2020Review
- The Prevalence of Selected Potential Drug-Drug Interactions of Analgesic Drugs and Possible Methods of Preventing Them: Lessons Learned From the Analysis of the Real-World National Database of 38 Million Citizens of Poland.Frontiers in pharmacology · 2020Article
- Hypertension in Cancer Patients and Survivors: Epidemiology, Diagnosis, and Management.JACC. CardioOncology · 2019Article
- Investigation of multimorbidity and prevalent disease combinations in older Irish adults using network analysis and association rules.Scientific reports · 2019Article
- Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis.Advances in pharmacological sciences · 2019Review
- Drug-Induced Hypertension: Focus on Mechanisms and Management.Current hypertension reports · 2017Review
- Label Propagation Prediction of Drug-Drug Interactions Based on Clinical Side Effects.Scientific reports · 2015Article
- PharmGKB summary: ibuprofen pathways.Pharmacogenetics and genomics · 2015Article
- Incidence of acute kidney injury following total joint arthroplasty: a retrospective review by RIFLE criteria.Clinical kidney journal · 2014Article
- Drug interactions--principles, examples and clinical consequences.Deutsches Arzteblatt international · 2012Review
- Evaluation of Bloodletting Cupping Therapy in the Management of Hypertension.Journal of pharmacy & bioallied sciencesArticle
- Concurrent prescribing: Evaluation of its knowledge among dentists.National journal of maxillofacial surgeryArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNon-steroidal anti-inflammatory drugs (NSAIDs) are known to antagonize the effects of antihypertensive drugs, and these associations can lead to an increase in arterial blood pressure. However, the impact of NSAIDs on hypertension treatment management in large-scale populations remains poorly evaluated. We examined whether the introduction of NSAID into the treatment regimen would induce an intensification of hypertension treatment (defined as the introduction of a new antihypertensive drug).
methodsWe conducted a cohort study involving 5,710 hypertensive subjects included in the French health insurance system database who had been treated and stabilized with their antihypertensive therapy and not exposed to any NSAID between 1 April 2005 and 1 April 2006. The maximum follow-up duration was 4 years.
resultsAdjusted hazard ratios (HR) for hypertension treatment intensification were 1.34 [95 % confidence interval (CI) 1.05-1.71] for NSAIDs in general, 1.79 (95 % CI 1.15-2.78) for diclofenac and 2.02 (95 % CI:1.09-3.77) for piroxicam. There were significant interactions between NSAIDs and angiotensin converting enzyme inhibitors (ACEIs; HR 4.09, 95 % CI 2.02-8.27) or angiotensin receptor blockers (ARBs; HR 3.62, 95 % CI 1.80-7.31), but not with other antihypertensive drugs.
conclusionsExposure to NSAIDs leads to an intensification of hypertension treatment, especially in patients treated with ACEIs or ARBs. Renin-angiotensin system blockers should be avoided whenever NSAIDs are prescribed.
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