ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2012
Adhesion/growth-regulatory galectins in the human eye: localization profiles and tissue reactivities as a standard to detect disease-associated alterations.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Integration of tear fluid biomarkers and machine learning for the early detection of keratoconus.BMC ophthalmology · 2025Article
- Galectin-3 Is a Crucial Immunological Disease Marker in Patients with Fungal Keratitis.Disease markers · 2022Article
- Galectins as Regulators of Corneal Inflammation.Current opinion in physiology · 2021Article
- Lectin-Glycan Interactions in Corneal Infection and Inflammation.Frontiers in immunology · 2018Review
- Network analysis of adhesion/growth-regulatory galectins and their binding sites in adult chicken retina and choroid.Journal of anatomy · 2017Article
- Galectin-9: From cell biology to complex disease dynamics.Journal of biosciences · 2016Review
- Sweet complementarity: the functional pairing of glycans with lectins.Cellular and molecular life sciences : CMLS · 2016Review
- Analysis of the effects of preservative-free tafluprost on the tear proteome.American journal of translational research · 2016Article
- Human osteoarthritic knee cartilage: fingerprinting of adhesion/growth-regulatory galectins in vitro and in situ indicates differential upregulation in severe degeneration.Histochemistry and cell biology · 2014Article
- Introduction to glycopathology: the concept, the tools and the perspectives.Diagnostic pathology · 2014Review
- Human tandem-repeat-type galectins bind bacterial non-βGal polysaccharides.Glycoconjugate journal · 2014Article
- Glycophenotyping of osteoarthritic cartilage and chondrocytes by RT-qPCR, mass spectrometry, histochemistry with plant/human lectins and lectin localization with a glycoprotein.Arthritis research & therapy · 2013Article
- The ocular surface epithelial barrier and other mechanisms of mucosal protection: from allergy to infectious diseases.Current opinion in allergy and clinical immunology · 2013Review
- In-depth mass spectrometric mapping of the human vitreous proteome.Proteome science · 2013Article
- The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity.Molecules (Basel, Switzerland) · 2013Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo characterize the localization profiles of seven adhesion/growth-regulatory galectins in the normal human eye using immunodetection of endogenous galectins and binding of labeled galectins to sections, useful as a basis to detect disease-associated alterations.
methodsNon-cross-reactive anti-galectin antibodies and biotinylated galectins were tested on acetone-fixed cryosections of normal human donor eyes. Controls included omission of first-step reagent, testing of an antibody against a galectin specific for rat (galectin-5), and blocking of galectin binding with lactose.
resultsGalectin presence was not restricted to one or few members of this family. Signal occurrence can even include all tested or most proteins (conjunctival or corneal epithelium), whereas choroid positivity is fully accounted for by galectin-9. Regional specificity and characteristic profiles for each protein, immuno- and galectin histochemically, were determined. Differences in tissue reactivity among the galectins were detected.
conclusionsThat the galectins have characteristic localization/reactivity profiles supports the concept of a network with potential for non-overlapping functions. The reported data thus prompt to proceed to the respective analysis of specimens from ocular diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.