ArticleJournal of neurology2012
Age-dependent effects of carotid endarterectomy or stenting on cognitive performance.
Article in Journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Clinical Significance of Carotid Endarterectomy and Carotid Artery Stenting in Older Patients Over 80.Neurologia medico-chirurgica · 2024Article
- Article
- Carotid revascularization and cognitive impairment: the neglected role of cerebral small vessel disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Cognitive Functions in Patients after Carotid Artery Revascularization-A Narrative Review.Brain sciences · 2021Review
- Silent brain infarcts on diffusion-weighted imaging after carotid revascularisation: A surrogate outcome measure for procedural stroke? A systematic review and meta-analysis.European stroke journal · 2019Article
- Is Hemispheric Hypoperfusion a Treatable Cause of Cognitive Impairment?Current cardiology reports · 2019Review
- Frequency-Dependent Changes of the Resting BOLD Signals Predicts Cognitive Deficits in Asymptomatic Carotid Artery Stenosis.Frontiers in neuroscience · 2018Article
- Failure to account for practice effects leads to clinical misinterpretation of cognitive outcome following carotid endarterectomy.Physiological reports · 2017Article
- Patients with carotid atherosclerosis who underwent or did not undergo carotid endarterectomy: outcome on mood, cognition and quality of life.BMC psychiatry · 2015Article
- Stroke: an update.Journal of neurology · 2014Review
- Neurocognitive functioning after carotid revascularization: a systematic review.Cerebrovascular diseases extra · 2014Review
- Complement polymorphisms and cognitive dysfunction after carotid endarterectomy.Journal of neurosurgery · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although evidence is accumulating that age modifies the risk of carotid angioplasty and stenting (CAS) versus endarterectomy (CEA) for patients with significant carotid stenosis, the impact of age on cognition after either CEA or CAS remains unclear. In this study, we analyzed the effects of age on cognitive performance after either CEA or CAS using a comprehensive neuropsychological test battery with parallel test forms and a control group to exclude a learning effect. The neuropsychological outcomes after revascularization were determined in 19 CAS and 27 CEA patients with severe carotid stenosis. The patients were subdivided according to their median age (<68 years and ≥68 years); 27 healthy subjects served as a control group. In all patients clinical examinations, MRI scans and a neuropsychological test battery that assessed four major cognitive domains were performed immediately before, within 72 h, and 3 months after CEA or CAS. While patients <68 years of age showed no significant cognitive alteration after either CEA or CAS, a significant cognitive decline was observed in patients ≥68 years in both treatment groups (p = 0.001). Notably, this cognitive deterioration persisted in patients after CEA, whereas it was only transient in patients treated with CAS. These results demonstrate an age-dependent effect of CEA and CAS on cognitive functions. In contrast to the recently observed increased clinical complication rates in older subjects after CAS compared with CEA, CEA appears to be associated with a greater, persistent decline in cognitive performance than CAS in this subgroup of patients.
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