ArticleClinical research in cardiology : official journal of the German Cardiac Society2012
Evaluation of cardiac autonomic function by various indices in patients with primary premature ovarian failure.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis.Journal of ovarian research · 2022Pooled it
- Metabolic Changes in Patients with Premature Ovarian Insufficiency: Adipose Tissue Focus-A Narrative Review.Metabolites · 2025Review
- N terminal prohormone of brain natriuretic peptide is associated with improved heart rate recovery after treadmill exercise test.International journal of cardiology. Cardiovascular risk and prevention · 2023Article
- Relation of heart rate recovery after exercise to insulin resistance and chronic inflammation in otherwise healthy adolescents and adults: results from the National Health and Nutrition Examination Survey (NHANES) 1999-2004.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- Symptomatic arrhythmias due to syringomyelia-induced severe autonomic dysfunction.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
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10 authors at 1 institution in 1 country.
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Abstract
backgroundThe association between premature ovarian failure (POF) and cardiovascular diseases (CVD) was investigated previously, but none of the studies have looked at cardiac autonomic functions in these patients. In this study, we aimed to evaluate cardiac autonomic functions in patients with POF.
methodsWe enrolled 26 female patients (mean age 37.5 ± 10.1 years) with primary POF and 31 healthy subjects (mean age 37.5 ± 9.0 years). All participants underwent 24-h Holter recording. Heart rate recovery (HRR) indices were calculated by subtracting 1st-, 2nd- and 3rd-min heart rates from maximal heart rate. Heart rate variability (HRV) and heart rate turbulence (HRT) parameters were analyzed in all patients.
resultsBoth groups were similar with regard to age, gender, body mass index and left ventricular ejection fraction. Mean HRR1 (p = 0.018), HRR2 (p = 0.021) and HRR3 (p = 0.027) values were significantly higher in the control group. When HRV considered SDNN, SDANN, RMSSD, PNN50 and HF were significantly decreased in patients with POF compared to healthy controls, but LF and LF/HF were significantly higher in POF patients. Both HRT onset and slope were more abnormal in POF patients. Also, there was a significant correlation between HRR, HRV and HRT parameters and FSH, LH and estradiol levels.
conclusionOur study results suggest that cardiac autonomic function is impaired in patients with POF despite the absence of overt cardiac involvement and symptoms. Further studies are needed to elucidate the prognostic significance and clinical implications of impaired autonomic functions in patients with POF.
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