ArticleIntensive care medicine2012
Increase in use of non-invasive ventilation for infants with severe bronchiolitis is associated with decline in intubation rates over a decade.
Article in Intensive care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Helmet Continous Positive Airway Pressure (CPAP) Management and Positive End Expiratory Pressure (PEEP) Level Impact on Severe Bronchiolitis Admitted in Pediatric Intensive Care Units (PICUs)
Role of Type of Respiratory Circuit and Type of Ventilator on Asynchronies During Non-invasive Ventilation (NIV) in Children With Acute Respiratory Failure: an Interventional, Nonpharmacological Crossover Study
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- Guideline
- High flow nasal cannula therapy versus continuous positive airway pressure and nasal positive pressure ventilation in infants with severe bronchiolitis: a randomized controlled trial.The Pan African medical journal · 2021Trial
- High flow nasal cannula and continuous positive airway pressure therapy in treatment of viral bronchiolitis: a randomized clinical trial.European journal of pediatrics · 2020Trial
- High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study).Intensive care medicine · 2017Trial
- Prospective Multicentre Study on the Epidemiology and Current Therapeutic Management of Severe Bronchiolitis in Spain.BioMed research international · 2017Trial
- Neurally adjusted ventilatory assist (NAVA) allows patient-ventilator synchrony during pediatric noninvasive ventilation: a crossover physiological study.Critical care (London, England) · 2015Trial
- Non-Invasive Ventilation Failure in Pediatric ICU: A Machine Learning Driven Prediction.Diagnostics (Basel, Switzerland) · 2024Article
- First-Line Respiratory Support for Children With Hematologic Malignancy and Acute Respiratory Failure.Critical care explorations · 2024Article
- Association of Fluid Overload with Escalation of Respiratory Support and Endotracheal Intubation in Acute Bronchiolitis Patients.Journal of pediatric intensive care · 2024Article
- Critical care of severe bronchiolitis during shortage of ICU resources.EClinicalMedicine · 2024Review
- Increased bronchiolitis burden and severity after the pandemic: a national multicentric study.Italian journal of pediatrics · 2024Article
- A Retrospective Study of Complications of Enteral Feeding in Critically Ill Children on Noninvasive Ventilation.Nutrients · 2023Article
- Clinical Profile and Outcome of Children Requiring Noninvasive Ventilation (NIV).Indian journal of pediatrics · 2022Observational
- Comparison of high flow nasal cannula and non-invasive positive pressure ventilation in children with bronchiolitis: A meta-analysis of randomized controlled trials.Frontiers in pediatrics · 2022Article
- Urgent air transfers for acute respiratory infections among children from Northern Canada, 2005-2014.PloS one · 2022Article
- Risk Factors Associated with Mechanical Ventilation in Critical Bronchiolitis.Children (Basel, Switzerland) · 2021Article
- Procedural skill needs for Canadian paediatricians: A national profile.Paediatrics & child health · 2021Article
- Interhospital transport of children with bronchiolitis by a statewide emergency transport service.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2021Article
- Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study.Journal of anesthesia, analgesia and critical care · 2021Article
- Risk Factors for Noninvasive Ventilation Failure in Children Post-Hematopoietic Cell Transplant.Frontiers in oncology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo redress the paucity of studies evaluating non-invasive respiratory support in bronchiolitis patients.
methodsFollowing ethics committee approval, the clinical database of a tertiary 23-bed paediatric intensive care unit (PICU) was reviewed for bronchiolitis admissions from January 2000 to December 2009. Length of stay (LOS), ventilatory requirements and risk factors, including prematurity, respiratory syncytial virus (RSV) status, chronic lung, neuromuscular, immune and congenital heart disease, were analysed.
resultsOf 8,288 admissions, 520 (6.27 %) had bronchiolitis with 343 (65.9 %) having RSV. Median (±SD) age and LOS were 2.78 months and 2.68 (±4.32) days. One (0.2 %) patient died. Assisted ventilation was required for 399 (76.7 %) patients. A total of 114 (28.6 %) patients were intubated directly and 285 (71.4 %) had a trial of non-invasive ventilation (NIV). Significant increase in the use of NIV was seen (2.8 %/year) with decline in intubation rates (1.9 %/ year) (p = 0.002). Of NIV patients, 237 (83.2 %) needed only NIV and 48 (16.8 %) failed and therefore needed intubation. The median LOS was shorter in those who succeeded NIV (2.38 ± 2.43 days) compared to those with invasive ventilation (5.19 ± 6.34 days) and those who failed NIV (8.41 ± 3.44 days). Presence of a risk factor increased the chances of failing NIV from 6 to 10 %.
conclusionNIV was successful in the vast majority of patients, particularly in those without risk factors and halved the LOS in intensive care. Failure of NIV was associated with increased duration of invasive ventilation and PICU LOS. A prospective study comparing different techniques of NIV will be helpful in defining the risks of failure of NIV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.