SynthesisIntensive care medicine2012
Safety of gelatin for volume resuscitation--a systematic review and meta-analysis.
Synthesis in Intensive care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Randomised trials of human albumin for adults with sepsis: systematic review and meta-analysis with trial sequential analysis of all-cause mortality.BMJ (Clinical research ed.) · 2014Pooled it
- Albumin versus crystalloid solutions in patients with the acute respiratory distress syndrome: a systematic review and meta-analysis.Critical care (London, England) · 2014Pooled it
- Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis.BMJ (Clinical research ed.) · 2013Pooled it
- Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy.BioMed research international · 2018Trial
- [Rotational thromboelastometry assessment of ballanced crystalloid, hydroxyethyl starch and gelatin effects on coagulation: a randomized trial].Brazilian journal of anesthesiology (Elsevier)Trial
- Volume Kinetics of Gelofusine 4% During Vascular Surgery.Clinical pharmacokinetics · 2025Observational
- [Volume therapy: which preparation for which situation?]Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- Hyperoncotic human albumin solutions for intravenous fluid therapy: Effectiveness of pathogen safety and purification methods, and clinical safety.Biosafety and health · 2023Review
- Contemporary resuscitation of hemorrhagic shock: What will the future hold?American journal of surgery · 2020Review
- State of the art in fluid and volume therapy : A user-friendly staged concept. English version.Der Anaesthesist · 2019Article
- Choice of fluids in critically ill patients.BMC anesthesiology · 2018Review
- Starch Wars-New Episodes of the Saga. Changes in Regulations on Hydroxyethyl Starch in the European Union.Frontiers in veterinary science · 2018Review
- [State of the art in fluid and volume therapy : A user-friendly staged concept].Der Anaesthesist · 2017Review
- Cross-Sectional Guidelines for Therapy with Blood Components and Plasma Derivatives: Chapter 5 Human Albumin - Revised.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2016Article
- Effects of different types of fluid resuscitation for hemorrhagic shock on splanchnic organ microcirculation and renal reactive oxygen species formation.Critical care (London, England) · 2015Article
- Faulty risk-of-bias assessment in a meta-analysis of hydroxyethyl starch for nonseptic ICU patients.Critical care (London, England) · 2015Article
- Choices in fluid type and volume during resuscitation: impact on patient outcomes.Annals of intensive care · 2014Review
- Fluid management for the prevention and attenuation of acute kidney injury.Nature reviews. Nephrology · 2014Review
- [Hydroxyethyl starch].Der Anaesthesist · 2013Article
- Perioperative intravenous fluid therapy for adults.The Ulster medical journal · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGelatin is frequently used as a volume expander in critical care. Our goal was to investigate its safety.
methodsSystematic review of randomized controlled trials (RCT) in patients receiving gelatin for resuscitation in comparison to albumin or crystalloids.
resultsWe identified 40 RCTs published between 1976 and 2010 with 3,275 patients. Median sample size in the gelatin groups was 15 patients (range 10-249). Median gelatin dose was 17 ml/kg (range 6-57 ml/kg). In 32 RCTs (n = 1,946/3,275, 59 % of all patients), the study period was ≤24.0 h. Twenty-nine RCTs (n = 2,001) investigated elective surgical patients, mostly undergoing cardiac surgery (18 RCTs, n = 819). Three RCTs (n = 723) investigated critically ill adults. Two RCTs (n = 59) were performed in emergency room patients, and six RCTs (n = 492) were performed in neonates or children. No study was adequately powered to investigate the frequency of patient-important outcomes. Risks were not statistically significantly different for mortality (RR 1.12, 95 % confidence interval, 0.87-1.44) and exposure to allogeneic transfusion (RR 1.28, 0.89-1.83). On account of only few included studies and the small number of patients, subgroup analyses (high vs. low dose, >24 h vs. shorter periods, and critically ill patients vs. others) were uninformative. Only three RCTs reported the occurrence of acute renal failure.
conclusionDespite over 60 years of clinical practice, the safety and efficacy of gelatin cannot be reliably assessed in at least some settings in which it is currently used. We suggest the need to investigate and establish such safety.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.