Trial reportIntensive care medicine2012
In-line filtration reduces severe complications and length of stay on pediatric intensive care unit: a prospective, randomized, controlled trial.
Trial report in Intensive care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomised, Prospective Study of the Use of In-Line Filtration on the Reduction of Complication Rate in Critically Ill Children
Central Lines Filtration in Newborns: a Multicenter Randomized Controlled Trial
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Intravenous in-line filters for preventing morbidity and mortality in neonates.The Cochrane database of systematic reviews · 2015Pooled it
- In-line filtration in very preterm neonates: a randomized controlled trial.Scientific reports · 2020Trial
- Trial
- In-line Filtration Decreases Systemic Inflammatory Response Syndrome, Renal and Hematologic Dysfunction in Pediatric Cardiac Intensive Care Patients.Pediatric cardiology · 2015Trial
- In-line filtration minimizes organ dysfunction: new aspects from a prospective, randomized, controlled trial.BMC pediatrics · 2013Trial
- Strategies for Assessing Physical Compatibility of Calcium Folinate with Bicarbonate During Methotrexate Rescue Therapy in Pediatric Patients with Acute Lymphoblastic Leukemia.Pharmaceutics · 2025Article
- Use of failure mode and effect analysis to improve the monoclonal antibody drugs management process in pharmacy intravenous admixture services.Scientific reports · 2025Article
- Medication Safety in Intravenous Therapy: Compatibility of Etoposide with Frequently Drugs Used in Tumour Critical Care During Simulated Y-Site Administration.Drug design, development and therapy · 2025Article
- Article
- Spallation and particles infusion into the extracorporeal circuit during CRRT: a preventable phenomenon.Scientific reports · 2024Article
- Visible particles in parenteral drug products: A review of current safety assessment practice.Current research in toxicology · 2024Article
- Evaluation of Strategies for Reducing Vancomycin-Piperacillin/Tazobactam Incompatibility.Pharmaceutics · 2023Article
- Negative Outcomes Associated with Medication in Neonates on Parenteral Nutrition Therapy.Pediatric reports · 2023Article
- Exploring a case of incompatibility in a complex regimen containing Plasma-Lyte 148 in the pediatric intensive care.Paediatric anaesthesia · 2023Article
- A large amount of microscopic precipitates are inevitably injected during infusion therapy without an in-line filter.Oxford medical case reports · 2022Article
- Strategies to prevent drug incompatibility during simultaneous multi-drug infusion in intensive care units: a literature review.European journal of clinical pharmacology · 2021Review
- Optimising an Infusion Protocol Containing Cefepime to Limit Particulate Load to Newborns in a Neonatal Intensive Care Unit.Pharmaceutics · 2021Article
- Clinical evaluation of an interoperable clinical decision-support system for the detection of systemic inflammatory response syndrome in critically ill children.BMC medical informatics and decision making · 2021Article
- Paediatric parenteral nutrition: current issues.Frontline gastroenterology · 2020Article
- Incidence and Causes of Infusion Alarms in a Neonatal and Pediatric Intensive Care Unit: A Prospective Pilot Study.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeParticulate contamination due to infusion therapy carries a potential health risk for intensive care patients.
methodsThis single-centre, prospective, randomized controlled trial assessed the effects of filtration of intravenous fluids on the reduction of complications in critically ill children admitted to a pediatric intensive care unit (PICU). A total of 807 subjects were randomly assigned to either a control (n = 406) or filter group (n = 401), with the latter receiving in-line filtration. The primary endpoint was reduction in the rate of overall complications, which included the occurrence of systemic inflammatory response syndrome (SIRS), sepsis, organ failure (circulation, lung, liver, kidney) and thrombosis. Secondary objectives were a reduction in the length of stay on the PICU and overall hospital stay. Duration of mechanical ventilation and mortality were also analyzed.
findingsAnalysis demonstrated a significant reduction in the overall complication rate (n = 166 [40.9 %] vs. n = 124 [30.9 %]; P = 0.003) for the filter group. In particular, the incidence of SIRS was significantly lower (n = 123 [30.3 %] vs. n = 90 [22.4 %]; P = 0.01). Moreover the length of stay on PICU (3.89 [95 % confidence interval 2.97-4.82] vs. 2.98 [2.33-3.64]; P = 0.025) and duration of mechanical ventilation (14.0 [5.6-22.4] vs. 11.0 [7.1-14.9] h; P = 0.028) were significantly reduced.
conclusionIn-line filtration is able to avert severe complications in critically ill patients. The overall complication rate during the PICU stay among the filter group was significantly reduced. In-line filtration was effective in reducing the occurrence of SIRS. We therefore conclude that in-line filtration improves the safety of intensive care therapy and represents a preventive strategy that results in a significant reduction of the length of stay in the PICU and duration of mechanical ventilation (ClinicalTrials.gov number: NCT00209768).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.