ArticleEuropean journal of nuclear medicine and molecular imaging2012
Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease.
Article in European journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02969070 (Randomized Trial to Evaluate the Effects of Two Different Nutraceutical Therapies on Endothelial Function, Platelet Aggregation, and Coronary Flow Reserve in Hypercholesterolemic Patients at Moderate Cardiovascular Risk), which is not on this map. Cited by 35 papers.
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Randomized Trial to Evaluate the Effects of Two Different Nutraceutical Therapies on Endothelial Function, Platelet Aggregation, and Coronary Flow Reserve in Hypercholesterolemic Patients at Moderate Cardiovascular Risk
Who cites it
35 citing papers in PubMed, 55 citations in OpenAlex.
- Diabetes does not impact the diagnostic performance of contrast-based fractional flow reserve: insights from the CONTRAST study.Cardiovascular diabetology · 2017Trial
- Effects of a new combination of nutraceuticals with Morus alba on lipid profile, insulin sensitivity and endotelial function in dyslipidemic subjects. A cross-over, randomized, double-blind trial.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2015Trial
- Endovascular treatment of lower extremity arteries is associated with an improved outcome in diabetic patients affected by intermittent claudication.BMC surgery · 2012Trial
- Mechanobiology of the diabetic cardiomyocyte: insulin signaling, titin elasticity, and multiscale mechanical dysfunction.Biophysical reviews · 2026Review
- Review
- Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy.Cardiovascular research · 2023Review
- Coronary Microvascular Disease.Cardiology and therapy · 2022Review
- Metabolic, structural and biochemical changes in diabetes and the development of heart failure.Diabetologia · 2022Review
- Triglyceride-glucose index is associated with quantitative flow ratio in patients with acute ST-elevation myocardial infarction after percutaneous coronary intervention.Frontiers in cardiovascular medicine · 2022Article
- Review
- Clinical associations with stage B heart failure in adults with type 2 diabetes.Therapeutic advances in endocrinology and metabolism · 2021Article
- Prognostic significance of post-stress reduction in left ventricular ejection fraction with adenosine stress in Jordanian patients with normal myocardial perfusion.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Correlation between fractional flow reserve and instantaneous wave-free ratio with morphometric assessment by optical coherence tomography in diabetic patients.The international journal of cardiovascular imaging · 2020Article
- The metabolic syndrome in heart failure: insights to specific mechanisms.Heart failure reviews · 2020Review
- "Heart failure, whole-body insulin resistance and myocardial insulin resistance: An intriguing puzzle".Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Observational
- Biochemical Effects of Aqueous Extract of Persea americana (Mill) on the Myocardium of Left Ventricle of High Salt-Fed Adult Wistar Rats.Journal of evidence-based complementary & alternative medicine · 2017Article
- Is ischemia the only factor predicting cardiovascular outcomes in all diabetes mellitus patients?Cardiovascular diabetology · 2017Review
- Remarkable points for cardiovascular studies in fibromyalgia syndrome management.Clinical rheumatology · 2016Article
- Obesity Related Coronary Microvascular Dysfunction: From Basic to Clinical Practice.Cardiology research and practice · 2016Review
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe assessed the impact of type 2 diabetes, in the presence of other major cardiovascular risk factors, on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease (CAD).
methodsIn this prospective study, 23 patients with type 2 diabetes and 26 nondiabetic patients matched for age, sex and other cardiovascular risk factors underwent a cold pressure test (CPT) and dipyridamole transthoracic echocardiography to determine their coronary flow (CF) ratio. Within 2 weeks, all diabetic patients also underwent dipyridamole-rest myocardial perfusion single-photon emission (MPS) CT. None of the patients with or without diabetes had significant CAD on invasive coronary angiography.
resultsThe CPT-CF ratio was significantly lower in diabetic patients than in nondiabetic patients (1.46 ± 0.26 vs. 1.71 ± 0.32, p = 0.006) and was correlated significantly with fasting glycaemia (r = -0.35, p = 0.01), but not with glycated haemoglobin. The dipyridamole-CF ratio was also lower in diabetic patients than in nondiabetic patients (2.38 ± 0.74 vs. 2.75 ± 0.49, p = 0.04). On MPS imaging, 5 diabetic patients (22%) had stress-induced ischaemia and the remaining 18 (78%) had normal myocardial perfusion. The dipyridamole-CF ratio was not different in patients with and without reversible defects (2.3 ± 1.1 vs. 2.4 ± 0.6, p = 0.97).
conclusionCoronary microvascular function is impaired in type 2 diabetic patients without significant CAD, compared to nondiabetic patients with similar other cardiovascular risk factors. In the majority of diabetic patients, microvascular dysfunction is associated with normal myocardial perfusion.
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