ArticleExperimental brain research2012
Low-frequency galvanic vestibular stimulation evokes two peaks of modulation in skin sympathetic nerve activity.
Article in Experimental brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04976101 (A Pilot Study to Assess Sinusoidal Galvanic Vestibular Stimulation in Neurogenic Orthostatic Hypotension), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study to Assess Sinusoidal Galvanic Vestibular Stimulation in Neurogenic Orthostatic Hypotension
Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Frequency-Dependent Reduction of Cybersickness in Virtual Reality by Transcranial Oscillatory Stimulation of the Vestibular Cortex.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Trial
- Vestibular modulation of muscle sympathetic nerve activity by the utricle during sub-perceptual sinusoidal linear acceleration in humans.Experimental brain research · 2014Trial
- Hemodynamic Response to Air-Conducted Sound Stimulus Is Mediated via Vestibulosympathetic Reflex.Journal of clinical medicine · 2025Article
- Induced electric fields in MRI settings and electric vestibular stimulations: same vestibular effects?Experimental brain research · 2024Review
- The role of the dorsolateral prefrontal cortex in control of skin sympathetic nerve activity in humans.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Hypergravity load-induced hyperglycemia occurs due to hypothermia and increased plasma corticosterone level in mice.The journal of physiological sciences : JPS · 2022Article
- Nausea and Vomiting in 2021: A Comprehensive Update.Journal of clinical gastroenterology · 2021Review
- VGLUT2-expressing neurons in the vestibular nuclear complex mediate gravitational stress-induced hypothermia in mice.Communications biology · 2020Article
- Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environment.The journal of physiological sciences : JPS · 2020Review
- Random-amplitude sinusoidal linear acceleration causes greater vestibular modulation of skin sympathetic nerve activity than constant-amplitude acceleration.Experimental brain research · 2018Article
- Vestibular Activation Habituates the Vasovagal Response in the Rat.Frontiers in neurology · 2017Article
- Vestibular Modulation of Sympathetic Nerve Activity to Muscle and Skin in Humans.Frontiers in neurology · 2017Review
- What is nausea? A historical analysis of changing views.Autonomic neuroscience : basic & clinical · 2017Review
- The vestibular system does not modulate fusimotor drive to muscle spindles in relaxed leg muscles of subjects in a near-vertical position.Journal of neurophysiology · 2016Article
- Skin Sympathetic Nerve Activity is Modulated during Slow Sinusoidal Linear Displacements in Supine Humans.Frontiers in neuroscience · 2016Article
- Motion sickness is associated with an increase in vestibular modulation of skin but not muscle sympathetic nerve activity.Experimental brain research · 2015Article
- Controlled vestibular stimulation: a physiological method of stress relief.Journal of clinical and diagnostic research : JCDR · 2014Article
- Projection neurons of the vestibulo-sympathetic reflex pathway.The Journal of comparative neurology · 2014Article
- Vestibulo-sympathetic responses.Comprehensive Physiology · 2014Review
- Vestibular modulation of muscle sympathetic nerve activity during sinusoidal linear acceleration in supine humans.Frontiers in neuroscience · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that sinusoidal galvanic vestibular stimulation (sGVS), delivered bilaterally at 0.2-2.0 Hz, evokes a potent entrainment of sympathetic outflow to muscle and skin. Most recently, we showed that stimulation at 0.08-0.18 Hz generates two bursts of modulation of muscle sympathetic nerve activity (MSNA), more pronounced at 0.08 Hz, which we interpreted as reflecting bilateral projections from the vestibular nuclei to the medullary nuclei responsible for the generation of MSNA. Here, we test the hypothesis that these very low frequencies of sGVS modulate skin sympathetic nerve activity (SSNA) in a similar fashion. SSNA was recorded via tungsten microelectrodes inserted into the left common peroneal nerve in 11 awake-seated subjects. Bipolar binaural sGVS (±2 mA, 100 cycles) was applied to the mastoid processes at 0.08, 0.13 and 0.18 Hz. As with MSNA, cross-correlation analysis revealed two bursts of modulation of SSNA for each cycle of stimulation but, unlike MSNA, this modulation was equally pronounced at all frequencies. These results further support our conclusion that bilateral sGVS causes cyclical modulation of the left and right vestibular nerves and a resultant modulation of sympathetic outflow that reflects the summed activity of bilateral projections from the vestibular nuclei onto, in this case, the primary output nuclei responsible for SSNA-the medullary raphé. Furthermore, these findings emphasise the role of the vestibular system in the control of skin sympathetic outflow, and the cutaneous expression of motion sickness: pallor and sweat release. Indeed, vestibular modulation of SSNA was higher in those subjects reporting nausea than in those who did not report nausea during this low-frequency sGVS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.