ArticleJournal of mathematical biology2013
Inverse problems from biomedicine: inference of putative disease mechanisms and robust therapeutic strategies.
Article in Journal of mathematical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Efficient parameterization of large-scale dynamic models based on relative measurements.Bioinformatics (Oxford, England) · 2020Article
- Assessing the Dynamics and Complexity of Disease Pathogenicity Using 4-Dimensional Immunological Data.Frontiers in immunology · 2019Article
- Scalable Parameter Estimation for Genome-Scale Biochemical Reaction Networks.PLoS computational biology · 2017Article
- A method for inverse bifurcation of biochemical switches: inferring parameters from dose response curves.BMC systems biology · 2014Article
- Differentiation between genomic and non-genomic feedback controls yields an HPA axis model featuring hypercortisolism as an irreversible bistable switch.Theoretical biology & medical modelling · 2013Article
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Authors and funding
3 authors.
Funding
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Abstract
Many complex diseases that are difficult to treat cannot be mapped onto a single cause, but arise from the interplay of multiple contributing factors. In the study of such diseases, it is becoming apparent that therapeutic strategies targeting a single protein or metabolite are often not efficacious. Rather, a systems perspective describing the interaction of physiological components is needed. In this paper, we demonstrate via examples of disease models the kind of inverse problems that arise from the need to infer disease mechanisms and/or therapeutic strategies. We identify the challenges that arise, in particular the need to devise strategies that are robust against variable physiological states and parametric uncertainties.
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