Trial reportJournal of the Association for Research in Otolaryngology : JARO2012
Temporary suppression of tinnitus by modulated sounds.
Trial report in Journal of the Association for Research in Otolaryngology : JARO, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- The longer, the better? Investigating the effect of prolonged acoustic stimulation on brief acoustic tinnitus suppression.BMC neurology · 2026Trial
- Tailor-made notched music training-induced residual inhibition in subjective tinnitus: resting-state EEG spectral power ratio evidence.Frontiers in neuroscience · 2026Trial
- Effect of Combining Sound Therapy with Pharmacotherapy on the Recovery of Hearing Abilities in the Case of Sudden Sensorineural Hearing Loss: A Prospective Study.Advances in therapy · 2022Trial
- Trial
- The auditory sensitivity is increased in tinnitus ears.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Efficacy and safety of a modified sound therapy for patients with subjective tinnitus (MOST): a multicentre, double-blind, randomised controlled trial.EClinicalMedicine · 2025Article
- Prediction of acoustic tinnitus suppression using resting-state EEG via explainable AI approach.Scientific reports · 2025Article
- Customized strategies for managing cochlear implant stimulation side effects.Cochlear implants international · 2025Article
- Digital Frequency Customized Relieving Sound for Chronic Subjective Tinnitus Management: Prospective Controlled Study.Journal of medical Internet research · 2025Article
- Establishing a Comprehensive Tinnitus Care Pathway-Part 1: Essential Components.Seminars in hearing · 2024Review
- Attention-Modulated Cortical Responses as a Biomarker for Tinnitus.Brain sciences · 2024Article
- A Pilot Study to Evaluate a Residual Inhibition Technique in Hearing Aids for Suppression of Tinnitus.Seminars in hearing · 2024Review
- EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training.Frontiers in neuroscience · 2023Article
- Adapting Personal Therapies Using a Mobile Application for Tinnitus Rehabilitation: A Preliminary Study.The Annals of otology, rhinology, and laryngology · 2021Article
- Sound Generator: Analysis of the Effectiveness of Noise in the Habituation of Tinnitus.International archives of otorhinolaryngology · 2021Article
- Prediction of Acoustic Residual Inhibition of Tinnitus Using a Brain-Inspired Spiking Neural Network Model.Brain sciences · 2021Article
- Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers.Frontiers in aging neuroscience · 2021Review
- Sense and Sensibility: A Review of the Behavioral Neuroscience of Tinnitus Sound Therapy and a New Typology.Current topics in behavioral neurosciences · 2021Review
- Tinnitus Does Not Interfere with Auditory and Speech Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The state of the art of sound therapy for subjective tinnitus in adults.Therapeutic advances in chronic disease · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Despite high prevalence of tinnitus and its impact on quality life, there is no cure for tinnitus at present. Here, we report an effective means to temporarily suppress tinnitus by amplitude- and frequency-modulated tones. We systematically explored the interaction between subjective tinnitus and 17 external sounds in 20 chronic tinnitus sufferers. The external sounds included traditionally used unmodulated stimuli such as pure tones and white noise and dynamically modulated stimuli known to produce sustained neural synchrony in the central auditory pathway. All external sounds were presented in a random order to all subjects and at a loudness level that was just below tinnitus loudness. We found some tinnitus suppression in terms of reduced loudness by at least one of the 17 stimuli in 90% of the subjects, with the greatest suppression by amplitude-modulated tones with carrier frequencies near the tinnitus pitch for tinnitus sufferers with relatively normal loudness growth. Our results suggest that, in addition to a traditional masking approach using unmodulated pure tones and white noise, modulated sounds should be used for tinnitus suppression because they may be more effective in reducing hyperactive neural activities associated with tinnitus. The long-term effects of the modulated sounds on tinnitus and the underlying mechanisms remain to be investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.