SynthesisPediatric surgery international2012
The timing of ostomy closure in infants with necrotizing enterocolitis: a systematic review.
Synthesis in Pediatric surgery international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The impact of early stoma closure on infants after surgery for necrotizing enterocolitis (NEC): real-world data analysis.Updates in surgery · 2026Article
- Necrotizing enterocolitis.Nature reviews. Disease primers · 2026Review
- Risk factors for complications after infantile enterostomy: development of a clinical prediction model.Frontiers in public health · 2025Article
- Ultrasound assessment of abdominal adhesions in neonates: data over dogma for re-operative timing.Pediatric surgery international · 2023Observational
- Predictors of Morbidity Following Enterostomy Closure in Infants: An American College of Surgeons Pediatric National Surgical Quality Improvement Program Database Analysis.Hawai'i journal of health & social welfare · 2021Article
- Observational
- The Optimal Timing of Enterostomy Closure in Extremely Low Birth Weight Patients for Acute Abdomen.Scientific reports · 2018Article
- Outcome of stoma closure in babies with necrotising enterocolitis: early vs late closure.Pediatric surgery international · 2017Article
- Meconium-related ileus in very low birth weight and extremely low birth weight infants: immediate and one-year postoperative outcomes.Annals of surgical treatment and research · 2015Article
- Ileostomy Complications in Infants less than 1500 grams - Frequent but Manageable.Journal of neonatal surgeryArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe optimal timing of ostomy closure is a matter of debate. We performed a systematic review of outcomes of early ostomy closure (EC, within 8 weeks) and late ostomy closure (LC, after 8 weeks) in infants with necrotizing enterocolitis.
methodsPubMed, EMbase, Web-of-Science, and Cinahl were searched for studies that detailed time to ostomy closure, and time to full enteral nutrition (FEN) or complications after ostomy closure. Patients with Hirschsprung's disease or anorectal malformations were excluded. Analysis was performed using SPSS 17 and RevMan 5.
resultsOf 778 retrieved articles, 5 met the inclusion criteria. The median score for study quality was 9 [range 8-14 on a scale of 0 to 32 points (Downs and Black, J Epidemiol Community Health 52:377-384, 1998)]. One study described mean time to FEN: 19.1 days after EC (n = 13) versus 7.2 days after LC (n = 24; P = 0.027). Four studies reported complication rates after ostomy closure, complications occurred in 27% of the EC group versus 23% of the LC group. The combined odds ratio (LC vs. EC) was 1.1 [95% CI 0.5, 2.5].
conclusionEvidence that supports early or late closure is scarce and the published articles are of poor quality. There is no significant difference between EC versus LC in the complication rate. This systematic review supports neither early nor late ostomy closure.
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