Trial reportPsychopharmacology2012
Amphetamine as a social drug: effects of d-amphetamine on social processing and behavior.
Trial report in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Effects of LSD, DMT and psilocybin on cognitive and psychological functions: A systematic review of the literature.Journal of psychopharmacology (Oxford, England) · 2026Pooled it
- MDMA enhances positive affective responses to social feedback.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Acute effects of lisdexamfetamine and D-amphetamine on social cognition and cognitive performance in a placebo-controlled study in healthy subjects.Psychopharmacology · 2018Trial
- Effects of Buprenorphine on Responses to Emotional Stimuli in Individuals with a Range of Mood Symptomatology.The international journal of neuropsychopharmacology · 2018Trial
- Intimate insight: MDMA changes how people talk about significant others.Journal of psychopharmacology (Oxford, England) · 2015Trial
- Effects of acute doses of prosocial drugs methamphetamine and alcohol on plasma oxytocin levels.Journal of clinical psychopharmacology · 2015Trial
- A window into the intoxicated mind? Speech as an index of psychoactive drug effects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- In the company of others: social factors alter acute alcohol effects.Psychopharmacology · 2013Trial
- Interrogating roles for VTA dopamine neurons in locomotion and ultrasonic vocalizations elicited by different classes of rewarding drugs.Psychopharmacology · 2026Article
- Behavioral Effects of Stimulated Dopamine Release and D2-like Receptor Displacement in Parkinson's Patients with Impulse-Control Disorder.International journal of molecular sciences · 2025Article
- MDMA as well as amphetamine and alcohol increase feelings of social closeness in healthy adults.Scientific reports · 2024Article
- Drug-induced social connection: both MDMA and methamphetamine increase feelings of connectedness during controlled dyadic conversations.Scientific reports · 2023Article
- Social Psychopharmacology: Novel Approaches to Treat Deficits in Social Motivation in Schizophrenia.Schizophrenia bulletin · 2023Review
- Emotion recognition in individuals with cocaine use disorder: the role of abstinence length and the social brain network.Psychopharmacology · 2022Article
- Derationalizing Delusions.Clinical psychological science : a journal of the Association for Psychological Science · 2021Review
- Deficits in recognizing female facial expressions related to social network in cocaine-addicted men.Drug and alcohol dependence · 2020Article
- In the face of stress: Interpreting individual differences in stress-induced facial expressions.Neurobiology of stress · 2019Review
- Neural responses to cues paired with methamphetamine in healthy volunteers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Considering the context: social factors in responses to drugs in humans.Psychopharmacology · 2018Review
- The Effects of Housing Density on Social Interactions and Their Correlations with Serotonin in Rodents and Primates.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleDrug users often report using drugs to enhance social situations, and empirical studies support the idea that drugs increase both social behavior and the value of social interactions. One way that drugs may affect social behavior is by altering social processing, for example by decreasing perceptions of negative emotion in others.
objectivesWe examined effects of d-amphetamine on processing of emotional facial expressions and on the social behavior of talking. We predicted amphetamine would enhance attention, identification, and responsivity to positive expressions, and that this in turn would predict increased talkativeness.
methodsOver three sessions, 36 healthy normal adults received placebo, 10, and 20 mg d-amphetamine under counterbalanced double-blind conditions. At each session, we measured processing of happy, fearful, sad, and angry expressions using an attentional visual probe task, a dynamic emotion identification task, and measures of facial muscle activity. We also measured talking.
resultsAmphetamine decreased the threshold for identifying all emotions, increased negative facial responses to sad expressions, and increased talkativeness. Contrary to our hypotheses, amphetamine did not alter attention to, identification of, or facial responses to positive emotions specifically. Interestingly, the drug decreased the threshold to identify all emotions, and this effect was uniquely related to increased talkativeness, even after controlling for overall sensitivity to amphetamine.
conclusionsThe results suggest that amphetamine may encourage sociability by increasing sensitivity to subtle emotional expressions. These findings suggest novel social mechanisms that may contribute to the rewarding effects of amphetamine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.