ReviewHuman genetics2012
Genetics of smoking and depression.
Review in Human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Smoking and depressive symptoms: the mediating role of systemic inflammation in a US nationally representative sample.Annals of general psychiatry · 2026Article
- Nicotine dependence and incident psychiatric disorders: prospective evidence from US national study.Molecular psychiatry · 2025Article
- The bidirectional relationship between severity of obsessive-compulsive symptoms and lifestyle factors in patients with obsessive-compulsive disorder: a contemporaneous and prospective analysis.Frontiers in psychiatry · 2025Article
- Cigarette smoking and risk of suicide in bipolar disorder: a systematic review.Frontiers in psychiatry · 2023Review
- Article
- Prevalence of lifetime nonmedical opioid use among U.S. Health Center Patients aged 45 years and older with psychiatric disorders.Aging & mental health · 2022Article
- Is the Antidepressant Activity of Selective Serotonin Reuptake Inhibitors Mediated by Nicotinic Acetylcholine Receptors?Molecules (Basel, Switzerland) · 2021Review
- Cigarette Smoking and Health-related Quality of Life in the General Population of Iran: Independent Associations According to Gender.International journal of preventive medicine · 2019Article
- Depression Among Non-Daily Smokers Compared to Daily Smokers and Never-Smokers in the United States: An Emerging Problem.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men.Behavioral and brain functions : BBF · 2017Article
- A hierarchical causal taxonomy of psychopathology across the life span.Psychological bulletin · 2017Review
- Smoking history, and not depression, is related to deficits in detection of happy and sad faces.Addictive behaviors · 2015Article
- Depression and social functioning among HIV-infected and uninfected persons in South Africa.AIDS care · 2015Article
- Associations among smoking, anhedonia, and reward learning in depression.Behavior therapy · 2014Article
- SLC6A4 STin2 VNTR genetic polymorphism is associated with tobacco use disorder, but not with successful smoking cessation or smoking characteristics: a case control study.BMC genetics · 2014Article
- Article
- Using Mendelian randomisation to infer causality in depression and anxiety research.Depression and anxiety · 2013Review
- Pattern of drug use and depressive symptoms among amphetamine type stimulants users in Beijing and Guangdong province, China.PloS one · 2013Article
- The genetics of addiction.Human genetics · 2012Article
- Depression and substance abuse and dependency in relation to current smoking status and frequency of smoking among nondaily and daily smokers.The American journal on addictionsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smoking and depression are significant public health problems with multiple etiological dimensions and outcomes. Although each condition is important by itself, they are important because they often potentiate each other. Consequently, it is also essential to understand the nature their relationship. This representative review focuses on the genetic etiology of the relationship in the context of reviewing first the epidemiology of depression and smoking, and then by exploring behavioral and molecular genetic studies, and other psychiatric and medical comorbidities. At this point, epidemiological evidence for a relationship between depression and smoking/nicotine dependence is compelling. Although behavioral genetic results differ somewhat by gender and in accordance with specific definitions of depression and smoking variables, recent studies show converging evidence for common genetic factors underlying the relationship, often in addition to non-shared environmental factors. The search for underlying genes and genetic mechanisms is at an early stage, but shows promising candidate genes and genetic approaches for future studies.
Indexed as
Identifiers
22526528What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.