ArticleJournal of gastroenterology2012
Radially asymmetric gastroesophageal acid reflux in the distal esophagus: examinations with novel pH sensor catheter equipped with 8 pH sensors.
Article in Journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Evaluation of the circumferential location of mild reflux esophagitis (Grade A and B) in the lower esophagus.JGH open : an open access journal of gastroenterology and hepatology · 2022Article
- Mucosal color changes on narrow-band imaging in esophageal eosinophilic infiltration.Medicine · 2022Article
- Endoscopic diagnosis and screening of Barrett's esophagus: Inconsistency of diagnostic criteria between Japan and Western countries.DEN open · 2022Review
- Evaluations of Gastric Acid Pocket Using Novel Vertical 8-Channel pH Monitoring System and Effects of Acid Secretion Inhibitors.Journal of neurogastroenterology and motility · 2021Article
- Vertical and Circumferential Localization of Esophageal Mucosal Breaks in Patients with Mild Reflux Esophagitis.Internal medicine (Tokyo, Japan) · 2019Article
- Circumferential distribution and clinical characteristics of esophageal cancer in lower esophagus: differences related to histological subtype.Esophagus : official journal of the Japan Esophageal Society · 2019Article
- Mucosal breaks show same circumferential distribution in majority of patients with recurrent reflux esophagitis.Endoscopy international open · 2017Article
- Circumferential Locations of Different Shapes of Short-segment Barrett's Esophagus.Internal medicine (Tokyo, Japan) · 2017Article
- Correlation of the location of superficial Barrett's esophageal adenocarcinoma (s-BEA) with the direction of gastroesophageal reflux.Endoscopy international open · 2016Article
- Circumferential distribution and location of Mallory-Weiss tears: recent trends.Endoscopy international open · 2015Article
- Observations of Acid Reflux and Motor Function in Distal Esophagus Using Simultaneous Measurements of Intra-esophageal pH and Pressure in 8 Directions With Novel Sensor Catheter - A Feasibility Study.Journal of neurogastroenterology and motility · 2013Article
- Radial esophageal acid exposure and the dilated distal esophagus.Journal of gastroenterology · 2012Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEsophageal mucosal breaks in patients with Los Angeles (LA) grade A or B esophagitis are mainly found in the right anterior wall of the distal esophagus. The aim of this study was to reveal radial acid exposure in the distal esophagus and determine whether radial asymmetry of acid exposure is a possible cause of radially asymmetric distribution of the lesions.
methodsWe developed a novel pH sensor catheter using a polyvinyl chloride catheter equipped with 8 antimony pH sensors radially arrayed at the same level. Four healthy volunteers, 5 patients with non-erosive reflux disease (NERD), and 10 with LA grade A or B esophagitis were enrolled. The sensors were set 2 cm above the upper limit of the lower esophageal sphincter, and post-prandial gastroesophageal acid reflux was monitored for 3 h with the subjects in a sitting position.
resultsWe successfully examined radial acid exposure in the distal esophagus in all subjects using our novel pH sensor catheter. Radial variations of acid exposure in the distal esophagus were not observed in the healthy subjects. In contrast, the patients with NERD and those with reflux esophagitis had radial asymmetric acid exposure that was predominant on the right wall of the distal esophagus. In the majority of patients with reflux esophagitis, the directions of longer acid exposure coincided with the locations of mucosal breaks.
conclusionsRadial acid exposure could be examined using our novel 8-channel pH sensor catheter. We found that the directions of longer acid exposure were associated with the locations of mucosal breaks.
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