ArticleJournal of cancer research and clinical oncology2012
External validity of the Tokuhashi score in patients with vertebral metastasis.
Article in Journal of cancer research and clinical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Artificial Intelligence and Predictive Modeling in Spinal Oncology: A Narrative Review.International journal of spine surgery · 2023Article
- Prognostic Scoring System Development for Malignant Spinal Cord Compression.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- The Role of Prognostic Scoring Systems in Assessing Surgical Candidacy for Patients With Vertebral Metastasis: A Narrative Review.Global spine journal · 2018Review
- Usefulness of Tokuhashi Score in Survival Prediction of Patients Operated for Vertebral Metastatic Disease.Global spine journal · 2017Article
- Classification and scoring systems for metastatic spine tumors: a literature review.Spine surgery and related research · 2017Review
- The Tokuhashi score: effectiveness and pitfalls.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2016Review
- Accuracy of Tokuhashi score system in predicting survival of lung cancer patients with vertebral metastasis.Journal of neuro-oncology · 2015Article
- Tokuhashi score is predictive of survival in a cohort of patients undergoing surgery for renal cell carcinoma spinal metastases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2015Article
- Analysis of the predictive role and new proposal for surgical strategies based on the modified Tomita and Tokuhashi scoring systems for spinal metastasis.World journal of surgical oncology · 2014Article
- Scoring system for prediction of metastatic spine tumor prognosis.World journal of orthopedics · 2014Review
- [Solitary spinal metastases. Is aggressive surgical management justified?].Der Orthopade · 2013Article
- Prognostic Factors for Bone Survival and Functional Outcomes in Patients With Breast Cancer Spine Metastases.Technology in cancer research & treatmentReview
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4 authors.
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Abstract
purposeTo calculate the accuracy of the Tokuhashi score (TS) in recent patients with vertebral metastasis (VM), candidates or not to surgical treatment, and thus to assess the external validity of TS.
methodsRetrospective analysis of prospectively collected data from 90 patients (55 men, 35 women) with VM between 2004 and 2006. For each patient, data on the primary tumor (PT), date of diagnosis, TS at the time of VM diagnosis and date of death were retrieved from the electronic medical records and civil registry. True survival time and TS survival time were estimated to calculate the accuracy rate of the TS. A Kaplan-Meier analysis was used to study the survival function by prognostic groups. A correlation study between survival time and other variables was performed.
resultsPT distribution was as follows: breast (22.2 %), lung (20 %), prostate (17.8 %), rectum (10 %), unknown (11 %), and others (18 %). Average overall survival after the VM diagnosis was 11.8 months (SD, 11 m): breast, 20 months (SD, 20 m); lung, 5.8 months (SD, 5.9 m); prostate, 14.5 months (SD, 13.4 m); rectum, 9.4 months (SD, 9.3); and unknown tumors, 2.7 months (SD, 5 m). Survival time was accurately predicted with the TS in 63 % of patients with a short life expectancy (survival, <6 months; TS, 0-8), 16 % of patients in the intermediate group (survival, 6-12 months; TS, 9-11), and 77 % of patients with a good prognosis (survival >12 months; TS, 12-15). By specific PT, the accuracy rate of the TS was low for breast cancer metastasis (35 %). The Kaplan-Meier curves show a significant separation among the prognostic groups (p < 0.05), but the log-rank test showed a statistically significant difference in survival only between short expectancy group and good prognostic group. Age at PT diagnosis and at VM diagnosis negatively correlated with survival (r = 0.22; p = 0.032 and r = 0.3, p = 0.04).
conclusionsThe TS was not highly accurate for predicting survival in patients with VM, treated or not surgically, and it was particularly imprecise in patients with an intermediate score (9-11 points) and those with breast cancer, so it is possible that the TS currently has a poor external validity.
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