ArticleJournal of cancer research and clinical oncology2012
EGFR L861Q mutation is a frequent feature of pulmonary mucoepidermoid carcinoma.
Article in Journal of cancer research and clinical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- [Clinical Characteristics, MAML2 Gene Rearrangement and Prognosis of Pulmonary Mucoepidermoid Carcinoma].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025Article
- Reappraisal of Oncocytic Adenocarcinoma: Unveiling Its Connection to Oncocytic Variants of Salivary Duct Carcinoma and Mucoepidermoid Carcinoma Through ImmunoHisto-Molecular Perspectives.The American journal of surgical pathology · 2025Article
- An elderly woman with acute respiratory failure and diffuse pulmonary changes.Breathe (Sheffield, England) · 2024Article
- Targeted therapy for rare lung cancers: Status, challenges, and prospects.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Review
- Pulmonary Salivary Gland Tumor, Mucoepidermoid Carcinoma: A Literature Review.Journal of oncology · 2022Review
- Nomogram for predicting the survival rate of primary pulmonary mucoepidermoid carcinoma patients: a retrospective study based on SEER database.Annals of translational medicine · 2021Article
- Photodynamic therapy for pulmonary mucoepidermoid carcinoma.Respiratory medicine case reports · 2021Article
- Molecular and Morphological Profiling of Lung Cancer: A Foundation for "Next-Generation" Pathologists and Oncologists.Cancers · 2019Review
- A Rare Case of Pulmonary Mucoepidermoid Carcinoma in an 81-Year-Old Male.The American journal of case reports · 2018Article
- Clinicopathological characteristics and molecular analysis of primary pulmonary mucoepidermoid carcinoma: Case report and literature review.Thoracic cancer · 2018Article
- Primary mucoepidermoid carcinoma of the lung with prominent clear cells.Proceedings (Baylor University. Medical Center) · 2017Article
- Clinicopathologic and genetic features of primary bronchopulmonary mucoepidermoid carcinoma: the MD Anderson Cancer Center experience and comprehensive review of the literature.Virchows Archiv : an international journal of pathology · 2017Review
- [Mucoepidermoid Carcinoma of the Lung: Report of 29 Cases].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2017Article
- Erlotinib and gefitinib responsiveness in head and neck cancer cell lines--a comparing analysis with cetuximab.Clinical oral investigations · 2016Article
- Childhood and adolescent tracheobronchial mucoepidermoid carcinoma (MEC): a case-series and review of the literature.Pediatric surgery international · 2016Review
- Primary Pulmonary Mucoepidermoid Carcinoma: Histopathological and Moleculargenetic Studies of 26 Cases.PloS one · 2015Article
- Mucoepidermoid carcinoma of lung masquerading as urothelial carcinoma of bladder.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2014Article
- Mucoepidermoid carcinoma of the lung: a case report and literature review.Case reports in oncological medicine · 2013Article
- EGFR L861Q Mutation in a Metastatic Solid-pseudopapillary Neoplasm of the Pancreas.Cancer genomics & proteomicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to assess the feasibility of targeted treatment for pulmonary mucoepidermoid carcinoma (PMEC) by investigating track record of the epidermal growth factor receptor (EGFR) mutation status in PMEC.
methodsFrom January 2001 to December 2009, 20 PMEC patients (11 males and 9 females) received treatment in our center. All the patients received surgery and were diagnosed by pathology. Sequencing analysis was used to monitor exons 18-21 of the EGFR gene mutation.
resultsThe exon 21 L861Q heterozygous mutation was confirmed in five patients. There was no case with any deletion in exon 19 or exon 21 L858R mutation. One case was with a homonymy exon 18 mutation (I760I). Exon 20 G2607A (Q787Q) SNP was found in 12 of those 20 patients.
conclusionL861Q mutation in exon 21 is the most frequent feature of heterozygous mutation in our study. Further investigations will be required to validate our findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.