Evidence map›Paper›PMID 22526147›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2012

Effects of exercise training on exercise capacity in patients with non-small cell lung cancer receiving targeted therapy.

Chueh-Lung Hwang, Chong-Jen Yu, Jin-Yuan Shih, Pan-Chyr Yang, Ying-Tai Wu

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 74 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 24 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02978521 narecruitingnot on this mapstarted 2016, after this paper: background citation

Effect of a Pulmonary Rehabilitation Program on Skeletal Muscle Mass, Pulmonary Function, Inflammatory Response and Overall Survival on Patients Diagnosed With Non-small-cell Advanced Cancer

TypeinterventionalSponsorInstituto Nacional de Cancerologia de MexicoRan2016 to 2027Enrolled94ConditionsPulmonary Rehabilitation, Sarcopenia, Quality of LifeArmsPulmonary rehabilitation
NCT04679233 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Feasibility and Preliminary Efficacy of Aerobic Exercise in Head and Neck Cancer Patients Undergoing Radiation Therapy

TypeinterventionalSponsorVanderbilt UniversityRan2021 to 2021Enrolled0ConditionsHead and Neck Neoplasm, RadiotherapyArmsPrescription aerobic exercise
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 24 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Nonpharmacological dyspnoea-relief strategies in lung cancer: a systematic review and network meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Effects of exercise on people living with advanced lung cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  5. Guideline
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  8. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
    Pooled it
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  11. Is physical activity effective against cancer-related fatigue in lung cancer patients? An umbrella review of systematic reviews and meta-analyses.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  14. High-intensity interval training effects in cardiorespiratory fitness of lung cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
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  17. Exercise prescription for symptoms and quality of life improvements in lung cancer patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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  19. Exercise training for advanced lung cancer.The Cochrane database of systematic reviews · 2019
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  20. Pooled it

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chueh-Lung HwangSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Floor 3, No.17, Xuzhou Road, Zhongzheng District, Taipei 100, Taiwan.
Chong-Jen Yu
Jin-Yuan Shih
Pan-Chyr Yang
Ying-Tai Wu
National Taiwan University Hospital · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePeak oxygen consumption (VO(2peak)) is an important predictive factor for long-term prognosis in patients with non-small cell lung cancer (NSCLC). The purpose of this study was to investigate whether 8 weeks of exercise training improves exercise capacity, as assessed by VO(2peak), and other related factors in patients with NSCLC receiving targeted therapy.

methodsA total of 24 participants with adenocarcinoma were randomly assigned to either the control group (n = 11) or the exercise group (n = 13). Subjects in the exercise group participated in individualized, high-intensity aerobic interval training of exercise. The outcome measures assessed at baseline and after 8 weeks were as follows: VO(2peak) and the percentage of predicted VO(2peak) (%predVO(2peak)), muscle strength and endurance of the right quadriceps, muscle oxygenation during exercise, insulin resistance as calculated by the homeostasis model, high-sensitivity C-reactive protein, and quality of life (QoL) questionnaire inventory.

resultsNo exercise-related adverse events were reported. After exercise training, VO(2peak) and %predVO(2peak) increased by 1.6 mL kg(-1) min(-1) and 5.3% (p < 0.005), respectively; these changes were associated with improvements in circulatory, respiratory, and muscular functions at peak exercise (all p = 0.001). The exercise group also had less dyspnea (p = 0.01) and favorably lower fatigue (p = 0.05) than baseline.

conclusionsPatients with NSCLC receiving targeted therapy have quite a low exercise capacity, even with a relatively high QoL. Exercise training appears to improve exercise capacity and alleviate some cancer-related symptoms.

Indexed as

Exercise ToleranceOxygen ConsumptionAdenocarcinomaAdultAgedC-Reactive ProteinDyspneaExercise TestExercise TherapyFatigueFemaleHumansInsulin ResistanceLung NeoplasmsMaleMiddle AgedC-Reactive Protein

Identifiers

PMID22526147
OpenAlexW2060835564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.