ArticleWorld journal of surgery2012
Rate of clinically significant postoperative pancreatic fistula in pancreatic neuroendocrine tumors.
Article in World journal of surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Open and minimally invasive pancreatic neoplasms enucleation: a systematic review.Surgical endoscopy · 2019Pooled it
- Pancreatic Neuroendocrine Tumors (panNETs): Analysis of Overall Survival of Nonsurgical Management Versus Surgical Resection.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Pooled it
- Postoperative Complications, In-Hospital Mortality and 5-Year Survival After Surgical Resection for Patients with a Pancreatic Neuroendocrine Tumor: A Systematic Review.World journal of surgery · 2016Pooled it
- Limited surgery for benign tumours of the pancreas: a systematic review.World journal of surgery · 2015Pooled it
- Enucleation vs Pancreatoduodenectomy for Benign and Low-Grade Pancreatic Head Tumors.JAMA surgery · 2026Article
- Predicting Factor for Occurrence of Postoperative Pancreatic Fistula in Patients with Pancreatic Neuroendocrine Tumors.Diagnostics (Basel, Switzerland) · 2025Article
- Enucleation for pancreatic neuroendocrine tumors: short- and long-term outcomes in a forty-year single-center experience.Endocrine oncology (Bristol, England) · 2025Article
- Minimally invasive enucleation of pancreatic tumors: The main pancreatic duct is no longer a restricted area.Heliyon · 2023Article
- Complications of surgery for gastro-entero-pancreatic neuroendocrine neoplasias.Langenbeck's archives of surgery · 2020Article
- The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors.Pancreas · 2020Article
- Unraveling Pancreatic Segmentation.World journal of surgery · 2018Review
- Surgical resection of pancreatic neuroendocrine neoplasm by minimally invasive surgery-the robotic approach?Gland surgery · 2018Review
- Laparoscopic surgery for pancreatic neoplasms: the European association for endoscopic surgery clinical consensus conference.Surgical endoscopy · 2017Article
- Evaluation and management of pancreatic lesions in patients with von Hippel-Lindau disease.Nature reviews. Clinical oncology · 2016Review
- Significance of preoperative radiographic pancreatic density in predicting pancreatic fistula after surgery for pancreatic neuroendocrine tumors.American journal of surgery · 2016Article
- Minimally Invasive Versus Open Pancreatic Surgery in Patients with Multiple Endocrine Neoplasia Type 1.World journal of surgery · 2016Article
- Postoperative Outcomes of Enucleation and Standard Resections in Patients with a Pancreatic Neuroendocrine Tumor.World journal of surgery · 2016Article
- Continuous suture of the pancreatic stump and Braun enteroenterostomy in pancreaticoduodenectomy.World journal of gastroenterology · 2015Article
- Pancreatic fistulae after pancreatic resections for neuroendocrine tumours compared with resections for other lesions.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2015Article
- Update on pancreatic neuroendocrine tumors.Gland surgery · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIn 2005, the International Study Group of Pancreatic Fistula (ISGPF) developed a definition and grading system for postoperative pancreatic fistula (POPF). The authors sought to determine the rate of POPF after enucleation and/or resection of pancreatic neuroendocrine tumors (PNET) and to identify clinical, surgical, or pathologic factors associated with POPF.
methodsA retrospective analysis of pancreatic enucleations and resections performed from March 1998 to April 2010. We defined a clinically significant POPF as a grade B that required nonoperative intervention and grade C.
resultsOne hundred twenty-two patients were identified; 62 patients had enucleations and 60 patients had resections of PNET. The rate of clinically significant POPF was 23.7 % (29/122). For pancreatic enucleation, the POPF rate was 27.4 % (17/62, 14 grade B, 3 grade C). The pancreatic resection group had a POPF rate of 20 % (12/60, 10 grade B, 2 grade C). This difference was not significant (p = 0.4). In univariate analyses, patients in the enucleation group with hereditary syndromes (p = 0.02) and non-insulinoma tumors (p = 0.02) had a higher POPF rate. Patients in the resection group with body mass index (BMI) > 25 (p < 0.01), multiple endocrine neoplasia type 1 (MEN-1; p < 0.01) and those who underwent simultaneous multiple procedures (p = 0.02) had a higher POPF rate. Multivariate analyses revealed that hereditary syndromes were able to predict POPF in the enucleation group, while having BMI > 25 and increasing lesion size were also associated with POPF in the group undergoing resection.
conclusionsWe found a clinically significant POPF rate after surgery in PNET to be 23.7 % with no difference by the type of operation. Our POPF rate is comparable to that reported in the literature for pancreatic resection for other types of tumors. Certain inherited genetic diseases-von Hippel-Lindau disease (VHL) and MEN-1-were associated with higher POPF rates.
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