Evidence map›Paper›PMID 22525764›Full record

ReviewMedicine and science in sports and exercise2012

Regulation of physiological and metabolic function of muscle by female sex steroids.

Espen E Spangenburg, Paige C Geiger, Leslie A Leinwand, Dawn A Lowe

Abstract readReview
In one paragraph

Review in Medicine and science in sports and exercise, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Cancer Cachexia.Advances in experimental medicine and biology · 2025
    Review
  6. Cancer Cachexia.Advances in experimental medicine and biology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes.Biochimica et biophysica acta. Molecular basis of disease · 2021
    Review
  17. Exercise as a therapy for cancer-induced muscle wasting.Sports medicine and health science · 2020
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Espen E SpangenburgDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, MD 21045, USA. espen@umd.edu
Paige C Geiger
Leslie A Leinwand
Dawn A Lowe
University of Colorado Boulder · USUniversity of Kansas · USUniversity of Maryland, College Park · USUniversity of Minnesota Medical Center · US

Funding

UNDERSTANDING THE ROLE OF SMALL RNAS IN ARABIDOPSIS POLLEN DEVELOPMENTP20RR016475 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI LUSHINGTON, GERALD H · 2001 to 2011
$38.1M
Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in FemalesR01AG031743 · NIA · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE · 2009 to 2026
$7.4M
Mediators of Cardiac AdaptationR01HL050560 · NHLBI · YESHIVA UNIVERSITY · PI LEINWAND, LESLIE ANNE · 1993 to 2011
$4.0M
IN VIVO MODELS OF CARDIAC GENE REGULATIONR37HL050560 · NHLBI · YESHIVA UNIVERSITY · PI LEINWAND, LESLIE ANNE · 1993 to 2002
$1.3M
Targeting stress-mediated pathways in the treatment of muscle insulin resistanceR01AG031575 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI GEIGER, PAIGE C · 2010 to 2014
$1.2M
Estrogenic Effects on Aged MuscleK02AG036827 · NIA · UNIVERSITY OF MINNESOTA · PI LOWE, DAWN A · 2010 to 2013
$427k
NCRR NIH HHS P20 RR016475NHLBI NIH HHS NIH HL50560NHLBI NIH HHS R01 HL050560NHLBI NIH HHS R37 HL050560NIA NIH HHS AG031743NIA NIH HHS AG036827NIA NIH HHS K02 AG036827NIA NIH HHS NIH AG031575NIA NIH HHS R01 AG031575NIA NIH HHS R01 AG031743
6 · The paper itself

Abstract

The ability of female sex steroids to regulate tissue function has long been appreciated; however, their role in the regulation of striated muscle function has received considerably less attention. The purpose of this symposium review was to document recent evidence indicating the role female sex steroids have in defining the functional characteristics of striated muscle. The presentations provide substantial evidence indicating that estrogens are critical to the physiological and metabolic regulations of striated muscle; thus, when considering women's health issues, striated muscle must included as an important target tissue along with other classically thought of estrogen-sensitive tissues.

Indexed as

EstrogensFemaleGlucoseGonadal Steroid HormonesHumansMaleMuscle, SkeletalReceptors, EstrogenEstrogensGlucoseGonadal Steroid HormonesReceptors, Estrogen

Identifiers

PMID22525764
PMCPMC3422439
OpenAlexW2043790950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.