Evidence map›Paper›PMID 22525110›Full record

ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2012

Predictors of highly active antiretroviral therapy utilization for behaviorally HIV-1-infected youth: impact of adult versus pediatric clinical care site.

Allison L Agwu, George K Siberry, Jonathan Ellen, John A Fleishman, Richard Rutstein, Aditya H Gaur, P Todd Korthuis, Robert Warford, Stephen A Spector, Kelly A Gebo

Abstract read
In one paragraph

Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Frontiers in reproductive health · 2021
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Age Matters: Increased Risk of Inconsistent HIV Care and Viremia Among Adolescents and Young Adults on Antiretroviral Therapy in Nigeria.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2016
    Article
  12. The status of adolescent medicine: building a global adolescent workforce.International journal of adolescent medicine and health · 2016
    Review
  13. Article
  14. Article
  15. Aging and loss to follow-up among youth living with human immunodeficiency virus in the HIV Research Network.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2015
    Article
  16. Factors informing HIV providers' decisions to start antiretroviral therapy for young people living with behaviorally acquired HIV.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2014
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 1 country.

Allison L AgwuDivision of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA. ageorg10@jhmi.edu
George K Siberry
Jonathan Ellen
John A Fleishman
Richard Rutstein
Aditya H Gaur
P Todd Korthuis
Robert Warford
Stephen A Spector
Kelly A Gebo
Johns Hopkins University · USAgency for Healthcare Research and Quality · USChildren's Hospital of Philadelphia · USJohns Hopkins Medicine · USNational Institutes of Health · USOregon Health & Science University · USSt. Jude Children's Research Hospital · USSt. Luke's-Roosevelt Hospital Center · USUniversity of California, San Diego · US

Funding

Research Infrastructure for the Hopkins Population CenterR24HD042854 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHERLIN, ANDREW J · 2003 to 2017
$5.1M
Quality Outcomes for Patients with Drug Abuse and HIVK23DA019809 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KORTHUIS, PHILIP TODD · 2007 to 2011
$892k
HAART Initiation in Behaviorally HIV-Infected YouthK23AI084549 · NIAID · JOHNS HOPKINS UNIVERSITY · PI AGWU, ALLISON L · 2010 to 2013
$537k
CLINICAL OUTCOMES IN ELDERLY HIV PATIENTSR01AG026250 · NIA · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2006 to 2007
$197k
NIAID NIH HHS 1K23AI084549-01A1NIAID NIH HHS K23 AI084549NIA NIH HHS R01 AG026250NICHD NIH HHS R24 HD042854NIDA NIH HHS K23 DA019809NIDA NIH HHS K23DA019809PHS HHS 290-01-0012
6 · The paper itself

Abstract

objectivesWe evaluated highly active antiretroviral therapy (HAART) utilization in youth infected with HIV through risk behaviors who met treatment criteria for HAART. We assessed the impact of receiving care at an adult or pediatric HIV clinical site on initiation and discontinuation of the first HAART regimen in behaviorally infected youth (BIY).

methodsThis was a retrospective analysis of treatment-naive BIY, aged 12-24 years, who enrolled in the HIV Research Network between 2002 and 2008 and who met criteria for HAART. The outcomes were time from meeting criteria to initiation of HAART and time to discontinuation of the first HAART regimen. Analyses were conducted using Cox proportional hazards regression.

resultsOf 287 treatment-eligible youth, 198 (69%) received HAART; of these 198 youth, 58 (29.3%) subsequently discontinued HAART. In multivariable analyses, there was no significant difference in the time between meeting treatment criteria and initiating HAART for BIY followed at adult or pediatric HIV clinical sites. However, BIY followed at adult sites discontinued HAART sooner than BIY followed at pediatric HIV clinical sites (adjusted hazard ratio [AHR]: 3.19 [1.26-8.06]).

conclusionsTwo-thirds of treatment-eligible BIY in the HIV Research Network cohort initiated HAART; however, one-third who initiated HAART discontinued it during the study period. Identifying factors associated with earlier HAART initiation and sustainability can inform interventions to enhance HAART utilization among treatment-eligible youth. The finding of earlier HAART discontinuation for youth at adult care sites deserves further study.

Indexed as

HIV-1Medication AdherenceAdolescentAdultAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveChildFemaleHealth FacilitiesHIV InfectionsHumansKaplan-Meier EstimateMalePediatricsProportional Hazards ModelsRetrospective StudiesAnti-Retroviral Agents

Identifiers

PMID22525110
PMCPMC3338204
OpenAlexW2141926610

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.