ArticleBipolar disorders2012
Trait and state corticostriatal dysfunction in bipolar disorder during emotional face processing.
Article in Bipolar disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- A Multi-Dimensional and Integrative Approach to Examining the High-Risk and Ultra-High-Risk Stages of Bipolar Disorder.EBioMedicine · 2015Trial
- Neurofunctional Correlates of Response to Quetiapine in Adolescents with Bipolar Depression.Journal of child and adolescent psychopharmacologyTrial
- Changes in ventral prefrontal-subcortical network connectivity during the course of remission from bipolar mania.Journal of mood and anxiety disorders · 2025Article
- Pleiotropic effects of oxytocin receptor polymorphisms: influencing striatocortical connectivity in bipolar disorder.International journal of bipolar disorders · 2025Article
- Reward Processing in Mood Disorders and Schizophrenia: A Neurodevelopmental Framework.Annual review of clinical psychology · 2025Review
- Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder.Journal of affective disorders · 2024Article
- Advances in functional MRI research in bipolar disorder: from the perspective of mood states.General psychiatry · 2024Review
- Shared and disease-sensitive dysfunction across bipolar and unipolar disorder during depressive episodes: a transdiagnostic study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Obesity and Cerebral Blood Flow in the Reward Circuitry of Youth With Bipolar Disorder.The international journal of neuropsychopharmacology · 2022Article
- Test-retest stability of spontaneous brain activity and functional connectivity in the core resting-state networks assessed with ultrahigh field 7-Tesla resting-state functional magnetic resonance imaging.Human brain mapping · 2022Article
- Rethinking "aggression" and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features.Journal of affective disorders · 2022Article
- Emotion Processing Deficit in Euthymic Bipolar Disorder: A Potential Endophenotype.Indian journal of psychological medicine · 2022Article
- Functional neuroanatomy of mania.Translational psychiatry · 2022Review
- Graph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder.Translational psychiatry · 2022Article
- Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder.Bipolar disorders · 2021Article
- Decreased activity in the reward network of chronic insomnia patients.Scientific reports · 2021Article
- Resting-state functional connectivity of neural circuits associated with primary and secondary rewards in patients with bipolar disorder.Social cognitive and affective neuroscience · 2020Article
- Dysregulation of oxytocin and dopamine in the corticostriatal circuitry in bipolar II disorder.Translational psychiatry · 2020Article
- Vigilance, Inhibitory Control and Regional Cerebral Blood Oxygenation in the PFC - Differences in ADHD Types of Presentations.Advances in cognitive psychology · 2020Article
- Diverse pathophysiological processes converge on network disruption in mania.Journal of affective disorders · 2019Article
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6 authors.
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Abstract
objectivesConvergent evidence supports limbic, anterior paralimbic, and prefrontal cortex (PFC) abnormalities in emotional processing in bipolar disorder (BD) and suggests that some abnormalities are mood-state dependent and others persist into euthymia. However, few studies have assessed elevated, depressed, and euthymic mood states while individuals processed emotional stimuli of varying valence to investigate trait- and state-related neural system responses. Here, regional brain responses to positive, negative, and neutral emotional stimuli were assessed in individuals with BD during elevated, depressed, and euthymic mood states.
methodsOne hundred and thirty-four subjects participated in functional magnetic resonance imaging scanning while processing faces depicting happy, fearful, and neutral expressions: 76 with BD (18 in elevated mood states, 19 depressed, 39 euthymic) and 58 healthy comparison (HC) individuals. Analyses were performed for BD trait- and mood state-related features.
resultsVentral anterior cingulate cortex (VACC), orbitofrontal cortex (OFC), and ventral striatum responses to happy and neutral faces were decreased in the BD group, compared to the HC group, and were not influenced by mood state. Elevated mood states were associated with decreased right rostral PFC activation to fearful and neutral faces, and depression was associated with increased left OFC activation to fearful faces.
conclusionsThe findings suggest that abnormal VACC, OFC, and ventral striatum responses to happy and neutral stimuli are trait features of BD. Acute mood states may be associated with additional lateralized abnormalities of diminished right rostral PFC responses to fearful and neutral stimuli in elevated states and increased left OFC responses to fearful stimuli in depressed states.
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