ArticleImmunity & ageing : I & A2012
Genetics of longevity. data from the studies on Sicilian centenarians.
Article in Immunity & ageing : I & A, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Adherence to various dietary quality indices of centenarian offspring in the New England Centenarian Study.The journal of nutrition, health & aging · 2026Article
- Decoding brain aging trajectory: predictive discrepancies, genetic susceptibilities, and emerging therapeutic strategies.Frontiers in aging neuroscience · 2025Review
- Longevity, Centenarians and Modified Cellular Proteodynamics.International journal of molecular sciences · 2023Review
- Article
- Lessons from Sicilian Centenarians for Anti-Ageing Medicine. The Oxi-Inflammatory Status.Translational medicine @ UniSa · 2022Review
- Iron homeostasis and organismal aging.Ageing research reviews · 2021Review
- SARS CoV2 infection _The longevity study perspectives.Ageing research reviews · 2021Review
- On the Road to Accurate Biomarkers for Cardiometabolic Diseases by Integrating Precision and Gender Medicine Approaches.International journal of molecular sciences · 2019Review
- Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?Oxidative medicine and cellular longevity · 2019Review
- SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease.Scientific reports · 2018Article
- Paradoxical changes in innate immunity in aging: recent progress and new directions.Journal of leukocyte biology · 2015Review
- Ageing gender-specific "Biomarkers of Homeostasis", to protect ourselves against the diseases of the old age.Immunity & ageing : I & A · 2014Article
- Possible role of ABO system in age-related diseases and longevity: a narrative review.Immunity & ageing : I & A · 2014Review
- Prostate cancer: from the pathophysiologic implications of some genetic risk factors to translation in personalized cancer treatments.Cancer gene therapy · 2014Review
- Evidences of +896 A/G TLR4 polymorphism as an indicative of prevalence of complications in T2DM patients.Mediators of inflammation · 2014Article
- Gender-specific DNA methylome analysis of a Han Chinese longevity population.BioMed research international · 2014Article
- Can the TLR-4-mediated signaling pathway be "a key inflammatory promoter for sporadic TAA"?Mediators of inflammation · 2014Article
- Possible role of -374T/A polymorphism of RAGE gene in longevity.International journal of molecular sciences · 2013Article
- Prevalence of aging population in the Middle East and its implications on cancer incidence and care.Annals of oncology : official journal of the European Society for Medical Oncology · 2013Article
- Expression of calpain-calpastatin system (CCS) member proteins in human lymphocytes of young and elderly individuals; pilot baseline data for the CALPACENT project.Immunity & ageing : I & A · 2013Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The demographic and social changes of the past decades have determined improvements in public health and longevity. So, the number of centenarians is increasing as a worldwide phenomenon. Scientists have focused their attention on centenarians as optimal model to address the biological mechanisms of "successful and unsuccessful ageing". They are equipped to reach the extreme limits of human life span and, most importantly, to show relatively good health, being able to perform their routine daily life and to escape fatal age-related diseases, such as cardiovascular diseases and cancer. Thus, particular attention has been centered on their genetic background and immune system. In this review, we report our data gathered for over 10 years in Sicilian centenarians. Based on results obtained, we suggest longevity as the result of an optimal performance of immune system and an over-expression of anti-inflammatory sequence variants of immune/inflammatory genes. However, as well known, genetic, epigenetic, stochastic and environmental factors seem to have a crucial role in ageing and longevity. Epigenetics is associated with ageing, as demonstrated in many studies. In particular, ageing is associated with a global loss of methylation state. Thus, the aim of future studies will be to analyze the weight of epigenetic changes in ageing and longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.