Evidence map›Paper›PMID 22524422›Full record

ReviewAnnals of the New York Academy of Sciences2012

Glycobiology of immune responses.

Gabriel A Rabinovich, Yvette van Kooyk, Brian A Cobb

Open access · bronzeAbstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 276 citations in OpenAlex.

  1. Trial
  2. Polysaccharide Extracted from Longan (International journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. The Role of Glycans in Human Immunity-A Sweet Code.Molecules (Basel, Switzerland) · 2025
    Review
  13. Article
  14. The genetic landscape of pediatric postural orthostatic tachycardia syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  15. Article
  16. Review
  17. Implications of Mucin-TypeMolecules (Basel, Switzerland) · 2025
    Review
  18. CryoSeek II: Cryo-EM analysis of glycofibrils from freshwater reveals well-structured glycans coating linear tetrapeptide repeats.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Article
  20. Review

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Gabriel A RabinovichLaboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad de Buenos Aires, Argentina. gabyrabi@gmail.com
Yvette van Kooyk
Brian A Cobb
Amsterdam UMC Location VUmc · NLExperimental Medicine and Biology Institute · ARUniversity School · US

Funding

Antigenic Carbohydrate Structure, Function, and SpecificityR01GM082916 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2009 to 2016
$1.9M
T cell Dependent Immune Responses to Carbohydrate AntigensDP2OD004225 · OD · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2008 to 2008
$1.9M
T cell Response Defects to Commensal Glycoantigens in CGDR21AI079756 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2008 to 2009
$432k
NIAID NIH HHS AI079756NIAID NIH HHS R21 AI079756NIGMS NIH HHS GM082916NIGMS NIH HHS R01 GM082916NIH HHS DP2 OD004225NIH HHS OD004225
6 · The paper itself

Abstract

Unlike their protein "roommates" and their nucleic acid "cousins," carbohydrates remain an enigmatic arm of biology. The central reason for the difficulty in fully understanding how carbohydrate structure and biological function are tied is the nontemplate nature of their synthesis and the resulting heterogeneity. The goal of this collection of expert reviews is to highlight what is known about how carbohydrates and their binding partners-the microbial (non-self), tumor (altered-self), and host (self)-cooperate within the immune system, while also identifying areas of opportunity to those willing to take up the challenge of understanding more about how carbohydrates influence immune responses. In the end, these reviews will serve as specific examples of how carbohydrates are as integral to biology as are proteins, nucleic acids, and lipids. Here, we attempt to summarize general concepts on glycans and glycan-binding proteins (mainly C-type lectins, siglecs, and galectins) and their contributions to the biology of immune responses in physiologic and pathologic settings.

Indexed as

GlycomicsImmunityAnimalsAutoimmunityCarbohydratesGalectinsGlycosylationHumansImmunity, InnateInflammationLectinsLectins, C-TypeModels, ImmunologicalNeoplasmsPolysaccharidesSialic Acid Binding Immunoglobulin-like LectinsCarbohydratesGalectinsLectinsLectins, C-TypePolysaccharidesSialic Acid Binding Immunoglobulin-like Lectins

Identifiers

PMID22524422
PMCPMC3884643
OpenAlexW2142574184

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.