Evidence map›Paper›PMID 22524415›Full record

ArticleAlimentary pharmacology & therapeutics2012

Diagnostic utility of the oesophageal balloon distension test in the evaluation of oesophageal chest pain.

I Nasr, A Attaluri, E Coss-Adame, S S C Rao

Abstract read
In one paragraph

Article in Alimentary pharmacology & therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Diagnosis and Management of Noncardiac Chest Pain.Gastroenterology & hepatology · 2024
    Article
  3. Article
  4. Diagnosis and Management of Functional Chest Pain in the Rome IV Era.Journal of neurogastroenterology and motility · 2019
    Review
  5. Observational
  6. Review
  7. How to Diagnose and Treat Functional Chest Pain.Current treatment options in gastroenterology · 2016
    Review
  8. A Review of Esophageal Chest Pain.Gastroenterology & hepatology · 2015
    Article
  9. Treatment of esophageal (noncardiac) chest pain: an expert review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2014
    Review
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

I NasrUniversity of Iowa Hospitals and Clinics, Iowa City, USA.
A Attaluri
E Coss-Adame
S S C Rao

Funding

Novel Treatment Strategies for Constipation and Role of Brain-Gut axisR01DK057100 · NIDDK · UNIVERSITY OF IOWA · PI RAO, SATISH SC · 2000 to 2011
$2.7M
NIDDK NIH HHS R01 DK057100
6 · The paper itself

Abstract

backgroundOesophageal balloon distension test (EBDT) has been advocated for the evaluation of functional oesophageal noncardiac chest pain (NCCP), but its diagnostic utility remains unclear.

aimTo prospectively assess the diagnostic yield of EBDT in clinical practice and compare its yield with standard oesophageal tests.

methodsOver a period of 6 years, patients with chest pain and negative cardiac work-up underwent sequential testing with endoscopy/biopsy, oesophageal manometry, 24 h pH study and EBDT to elucidate an oesophageal source for their symptoms. Patients with a definite abnormality, for example, erosive oesophagitis on oesophagogastroduodenoscopy (EGD) were designated as having positive test and excluded from further work up.

resultsOf 348 (m/f = 105/243) suspected NCCP patients, 16 (5%) were excluded; 332 (95%) underwent oesophageal testing. Among these, 48 (14%) had macro/microscopic oesophagitis on endoscopy, 7 (2%) had achalasia and 96 (28%) had excessive acid reflux (pH study). The remaining 181 (52%) patients underwent EBDT; 128 (37%) had oesophageal hypersensitivity. Chest pain was reproduced in 97/128 (75%) subjects. There were no adverse effects.

conclusionsOesophageal testing can reveal an oesophageal source for chest pain in 86% of NCCP subjects. The majority (42%) of patients had gastro-oesophageal reflux disease (GERD). Oesophageal balloon distension test identified hypersensitivity in over one-third of subjects. The oesophageal balloon distension test provides useful diagnostic information and should be performed routinely in patients with NCCP after excluding GERD.

Indexed as

Severity of Illness IndexCatheterizationChest PainDilatation, PathologicEndoscopy, Digestive SystemFemaleGastroesophageal RefluxHumansMaleMiddle AgedProspective StudiesRisk Factors

Identifiers

PMID22524415
PMCPMC4470272

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.