ArticleImmunity & ageing : I & A2012
The application of genetics approaches to the study of exceptional longevity in humans: potential and limitations.
Article in Immunity & ageing : I & A, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- New Insights for BPIFB4 in Cardiovascular Therapy.International journal of molecular sciences · 2020Review
- Taste receptors, innate immunity and longevity: the case of TAS2R16 gene.Immunity & ageing : I & A · 2019Article
- Genetic cartography of longevity in humans and mice: Current landscape and horizons.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- Genetics of exceptional longevity: possible role of GM allotypes.Immunity & ageing : I & A · 2018Article
- Association of immunoglobulin GM allotypes with longevity in long-living individuals from Southern Italy.Immunity & ageing : I & A · 2018Article
- Four Genome-Wide Association Studies Identify New Extreme Longevity Variants.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Physical, cognitive, social and mental health in near-centenarians and centenarians living in New York City: findings from the Fordham Centenarian Study.BMC geriatrics · 2016Article
- Human longevity: Genetics or Lifestyle? It takes two to tango.Immunity & ageing : I & A · 2016Review
- Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis.Circulation research · 2015Article
- Genetics of healthy aging and longevity.Human genetics · 2013Review
- Endothelial nitric oxide synthase, vascular integrity and human exceptional longevity.Immunity & ageing : I & A · 2012Article
- Hallmarks of human "immunosenescence": adaptation or dysregulation?Immunity & ageing : I & A · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The average life-span of the population of industrialized countries has improved enormously over the last decades. Despite evidence pointing to the role of food intake in modulating life-span, exceptional longevity is still considered primarily an inheritable trait, as pointed out by the description of families with centenarian clusters and by the elevated relative probability of siblings of centenarians to become centenarians themselves. However, rather than being two separate concepts, the genetic origin of exceptional longevity and the more recently observed environment-driven increase in the average age of the population could possibly be explained by the same genetic variants and environmentally modulated mechanisms (caloric restriction, specific nutrients). In support of this hypothesis, polymorphisms selected for in the centenarian population as a consequence of demographic pressure have been found to modulate cellular signals controlled also by caloric restriction. Here, we give an overview of the recent findings in the field of the genetics of human exceptional longevity, of how some of the identified polymorphisms modulate signals also influenced by food intake and caloric restriction, of what in our view have been the limitations of the approaches used over the past years to study genetics (sib-pair-, candidate gene association-, and genome-wide association-studies), and briefly of the limitations and the potential of the new, high-throughput, next-generation sequencing techniques applied to exceptional longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.